Parkinson's Disease (PD) is a common and progressive neurodegenerative disorder
characterised by motor impairments as well as non-motor symptoms. While dopamine …

Mitochondria are key cell organelles in that they are responsible for energy production and
control many processes from signalling to cell death. The function of the mitochondrial …

Ferroptosis, triggered by discoordination of iron, thiols and lipids, leads to the accumulation
of 15-hydroperoxy (Hp)-arachidonoyl-phosphatidylethanolamine (15-HpETE-PE), generated …

The world's population aging progression renders age‐related neurodegenerative diseases
to be one of the biggest unsolved problems of modern society. Despite the progress in …

About 15% of patients with Parkinson disease (PD) have family history and 5–10% have a
monogenic form of the disease with Mendelian inheritance. To date, at least 23 loci and 19 …

The phospholipase A2 (PLA2) superfamily contains more than 50 enzymes in mammals that
are subdivided into several distinct families on a structural and biochemical basis. In …

Parkinson's disease is a common, progressive neurodegenerative disorder, affecting 3% of
those older than 75 years of age. Clinically, Parkinson's disease (PD) is associated with …

An emerging body of data suggests that lipid metabolism has an important role to play in the
aging process. Indeed, a plethora of dietary, pharmacological, genetic, and surgical lipid …

The recently identified ferroptotic cell death is characterized by excessive accumulation of
hydroperoxy-arachidonoyl (C20: 4)-or adrenoyl (C22: 4)-phosphatidylethanolamine (Hp …

Dopamine metabolism, alpha-synuclein pathology, and iron homeostasis have all been
implicated as potential contributors to the unique vulnerability of substantia nigra …