Biological aging involves an interplay of conserved and targetable molecular mechanisms,
summarized as the hallmarks of aging. Metformin, a biguanide that combats age-related …

Metformin is a well-known anti-diabetic drug that has been repurposed for several emerging
applications, including as an anti-cancer agent. It boasts the distinct advantages of an …

Background Ferroptosis is a newly defined form of regulated cell death characterized by the
iron-dependent accumulation of lipid peroxidation and is involved in various …

Aging is a natural process, which plays a critical role in the pathogenesis of a variety of
diseases, ie, aging-related diseases, such as diabetes, osteoarthritis, Alzheimer disease …

Epigenetic regulation of mitochondrial DNA (mtDNA) is an emerging and fast-developing
field of research. Compared to regulation of nucler DNA, mechanisms of mtDNA epigenetic …

Numerous studies have shown that epigenetic age—an individual's degree of aging based
on patterns of DNA methylation—can be computed and is associated with an array of factors …

Abnormal regulation and expression of microRNAs (miRNAs) has been documented in
various diseases including cancer. The miRNA let-7 (MIRLET7) family controls …

Autophagy is a mechanism that enables cells to maintain cellular homeostasis by removing
damaged materials and mobilizing energy reserves in conditions of starvation. Although …

There is a growing body of evidence that links epigenetic modifications to type 2 diabetes.
Researchers have more recently investigated effects of commonly used medications …

The deregulation of energetic and cellular metabolism is a signature of cancer cells. Thus,
drugs targeting cancer cell metabolism may have promising therapeutic potential. Previous …