During the past decade, an abundance of new evidence highlighted the importance of
inflammation in the development of chronic pathologies such as neurodegeneration, cancer …

Abstract Interleukin-6 (IL-6) is a pleiotropic cytokine with significant functions in the
regulation of the immune system. As a potent pro-inflammatory cytokine, IL-6 plays a pivotal …

Signal transducer and activator of transcription 3 (STAT3) is one of the crucial transcription
factors, responsible for regulating cellular proliferation, cellular differentiation, migration …

Signal transducer and activator of transcription‐3 (STAT‐3) is one of six members of a family
of transcription factors. It was discovered almost 15 years ago as an acute‐phase response …

Microglia, which contribute substantially to the tumor mass of glioblastoma, have been
shown to play an important role in glioma growth and invasion. While a large number of …

The use of nanomedicine for antitumor therapy has been extensively investigated for a long
time. Enhanced permeability and retention (EPR) effect-mediated drug delivery is currently …

Studies in the past few years have provided compelling evidence for the critical role of
aberrant Signal Transducer and Activator of Transcription 3 (STAT3) in malignant …

Proper placental development and function are central to the health of both the mother and
the fetus during pregnancy. A critical component of healthy placental function is the proper …

Ras is mutated to remain in the active oncogenic state in many cancers. As Ras has proven
difficult to target therapeutically, we searched for secreted, druggable proteins induced by …

Glioblastomas are the most common and most lethal primary brain tumor. Recent studies
implicate an important role for a restricted population of neoplastic cells (glioma stem cells …