This article presents a personal viewpoint of the shortcoming of conventional hemodynamic
resuscitation procedures in achieving organ perfusion and tissue oxygenation following …

Importance Hydroxyethyl starch is commonly used for volume resuscitation yet has been
associated with serious adverse events, including acute kidney injury and death. Clinical …

Purpose Hand-held vital microscopes (HVMs) were introduced to observe sublingual
microcirculatory alterations at the bedside in different shock states in critically ill patients …

Objectives: Sepsis induces microvascular alterations that may play an important role in the
development of organ dysfunction. However, the relationship of these alterations to systemic …

Background: Fluid resuscitation is the cornerstone of sepsis treatment. However, whether
balanced or unbalanced crystalloids or natural or synthetic colloids confer a survival …

Background Critically ill people may lose fluid because of serious conditions, infections (eg
sepsis), trauma, or burns, and need additional fluids urgently to prevent dehydration or …

Objective To assess the effects of fluid therapy with hydroxyethyl starch 130/0.38-0.45
versus crystalloid or albumin on mortality, kidney injury, bleeding, and serious adverse …

Abstract Background and purpose The Japanese Clinical Practice Guidelines for
Management of Sepsis and Septic Shock 2016 (J-SSCG 2016), a Japanese-specific set of …

Purpose Guidelines recommend crystalloids for fluid resuscitation in sepsis/shock and
switching to albumin in cases where crystalloids are insufficient. We evaluated …

Objective: The microcirculation of septic patients has been characterized only
semiquantitatively. Our goal was to characterize the sublingual microcirculation in healthy …