Adiponectin as link factor between adipose tissue and cancer

E Di Zazzo, R Polito, S Bartollino, E Nigro… - International Journal of …, 2019 - mdpi.com
Adipose tissue is a key regulator of energy balance playing an active role in lipid storage as
well as in synthesizing several hormones directly involved in the pathogenesis of obesity …

PI3K/PTEN/AKT signaling pathways in germ cell development and their involvement in germ cell tumors and ovarian dysfunctions

M De Felici, FG Klinger - International Journal of Molecular Sciences, 2021 - mdpi.com
Several studies indicate that the PI3K/PTEN/AKT signaling pathways are critical regulators
of ovarian function including the formation of the germ cell precursors, termed primordial …

MiR-503 modulates epithelial-mesenchymal transition in silica-induced pulmonary fibrosis by targeting PI3K p85 and is sponged by lncRNA MALAT1

W Yan, Q Wu, W Yao, Y Li, Y Liu, J Yuan, R Han… - Scientific Reports, 2017 - nature.com
Silicosis is a kind of chronic, progressive and incurable lung fibrotic diseases with largely
unknown and complex pathogenesis and molecular mechanisms. Mounting evidence …

The role of oxidative stress and hormones in controlling obesity

M Di Domenico, F Pinto, L Quagliuolo… - Frontiers in …, 2019 - frontiersin.org
The accumulation of adipose tissue in the body occurs because the energy introduced with
food and drink exceeds that expense, but to understand why this imbalance is established …

The crosstalk between prostate cancer and microbiota inflammation: nutraceutical products are useful to balance this interplay?

F Crocetto, M Boccellino, B Barone, E Di Zazzo… - Nutrients, 2020 - mdpi.com
The human microbiota shows pivotal roles in urologic health and disease. Emerging studies
indicate that gut and urinary microbiomes can impact several urological diseases, both …

How glutamate is managed by the blood–brain barrier

RA Hawkins, JR Viña - Biology, 2016 - mdpi.com
A facilitative transport system exists on the blood–brain barrier (BBB) that has been tacitly
assumed to be a path for glutamate entry to the brain. However, glutamate is a non-essential …

PDE1C deficiency antagonizes pathological cardiac remodeling and dysfunction

WE Knight, S Chen, Y Zhang… - Proceedings of the …, 2016 - National Acad Sciences
Cyclic nucleotide phosphodiesterase 1C (PDE1C) represents a major phosphodiesterase
activity in human myocardium, but its function in the heart remains unknown. Using genetic …

The role of curcumin in prostate cancer cells and derived spheroids

M Boccellino, P Ambrosio, A Ballini, D De Vito… - Cancers, 2022 - mdpi.com
Simple Summary In recent years, considerable efforts have been made to discover new
compounds useful for prostate cancer (PC) therapy and related clinical management …

Early modulation of circulating microRNAs levels in HER2-positive breast cancer patients treated with trastuzumab-based neoadjuvant therapy

S Di Cosimo, V Appierto, S Pizzamiglio… - International journal of …, 2020 - mdpi.com
Circulating microRNA (ct-miRNAs) are able to identify patients with differential response to
HER2-targeted therapy. However, their dynamics are largely unknown. We assessed 752 …

Network-based integration of disparate omic data to identify" silent players" in cancer

M Ruffalo, M Koyutürk, R Sharan - PLoS computational biology, 2015 - journals.plos.org
Development of high-throughput monitoring technologies enables interrogation of cancer
samples at various levels of cellular activity. Capitalizing on these developments, various …