Branched‐chain amino acids (BCAAs) appear to influence several synthetic and catabolic
cellular signaling cascades leading to altered phenotypes in mammals. BCAAs are most …

Leucine is a well-known activator of the mammalian target of rapamycin (mTOR). Because
mTOR signaling regulates several aspects of metabolism, the potential of leucine as a …

Metformin has been proposed to operate as an agonist of SIRT1, a nicotinamide adenine
dinucleotide (NAD+)-dependent deacetylase that mimics most of the metabolic responses to …

Branched chain amino acids (BCAA) and their derivatives are bioactive molecules with
pleiotropic functions in the human body. Elevated fasting blood BCAA concentrations are …

Currently, obesity has become a worldwide epidemic associated with Type 2 diabetes,
dyslipidemia, cardiovascular disease and chronic metabolic diseases. Emodin is one of the …

Loss of muscle mass and strength after disuse followed by impaired muscle recovery
commonly occurs with aging. Metformin and leucine individually have shown positive effects …

Obesity develops from an imbalance of energy homeostasis and is associated with chronic
low-grade inflammation in white adipose tissues (WAT). Inflammation is involved in the …

Obesity increases the risk of developing insulin resistance and diabetes and is a major
public health concern. Our previous study shows that dietary β‐hydroxy‐β‐methylbutyrate …

The GLUT4 and PI3K/AKT signaling pathways are the key sensors of energy status and they
regulate glucose and lipid metabolism. Phloretin activates the PI3K/AKT pathway by …

Impaired muscle recovery (size and strength) following a disuse period commonly occurs in
older adults. Many of these individuals are not able to adequately exercise due to pain and …