Our previous International Union of Basic and Clinical Pharmacology report on the
nomenclature and classification of adenosine receptors (2011) contained a number of …

Microglial cells, the resident macrophages of the central nervous system (CNS), exist in a
process-bearing, ramified/surveying phenotype under resting conditions. Upon activation by …

Summary The apolipoprotein E4 (APOE4) allele is associated with an increased risk of
Alzheimer disease and a decreased risk of glaucoma, but the underlying mechanisms …

Elevation of intraocular pressure (IOP) is a major risk factor for neurodegeneration in
glaucoma. Glial cells, which play an important role in normal functioning of retinal neurons …

Microglia, the resident immune cells of the brain and retina, are constantly engaged in the
surveillance of their surrounding neural tissue. During embryonic development they infiltrate …

This paper reviews the results of studies conducted on the role of caffeine in the
management of different neurological disorders, such as Parkinson's disease (PD) and …

Background Acute glaucoma, characterized by a sudden elevation in intraocular pressure
(IOP) and retinal ganglion cells (RGCs) death, is a major cause of irreversible blindness …

Adenosine signals through four distinct G protein-coupled receptors that are located at
various synapses, cell types and brain areas. Through them, adenosine regulates …

Microglial activation is associated with glaucoma. In the model of unilateral laser-induced
ocular hypertension (OHT), the time point at which the inflammatory process peaks remains …

Glaucoma is a retinal degenerative disease characterized by the loss of retinal ganglion
cells and damage of the optic nerve. Recently, we demonstrated that antagonists of …