G protein‐coupled receptors (GPCRs) and heterotrimeric G proteins play central roles in a
diverse array of cellular processes. As such, dysregulation of GPCRs and their coupled …

Abstract Chitinase 3-like 1 (CHI3L1) is a secreted glycoprotein that mediates inflammation,
macrophage polarization, apoptosis, and carcinogenesis. The expression of CHI3L1 is …

The genetic basis for Waldenström macroglobulinemia (WM) remains to be clarified.
Although 6q losses are commonly present, recurring gene losses in this region remain to be …

G protein–coupled receptors (GPCRs) play critical roles in regulating processes such as
cellular homeostasis, responses to stimuli, and cell signaling. Accordingly, GPCRs have …

Malignant ovarian tumors bear the highest mortality rate among all gynecological cancers.
Both late tumor diagnosis and tolerance to available chemical therapy increase patient …

Lysophosphatidic acid (LPA) is a bioactive lipid mediator primarily derived from membrane
phospholipids. LPA initiates cellular effects upon binding to a family of G protein-coupled …

The RGS (regulator of G protein signaling) gene family, which includes negative regulators
of G protein-coupled receptors, comprises important drug targets for malignant tumors. It is …

Ovarian cancer typically presents at an advanced stage, and although the majority of cases
initially respond well to platinum-based therapies, chemoresistance almost always occurs …

We developed an innovative hybrid sequencing approach, IDP-fusion, to detect fusion
genes, determine fusion sites and identify and quantify fusion isoforms. IDP-fusion is the first …

RGS10 is an important regulator of cell survival and chemoresistance in ovarian cancer. We
recently showed that RGS10 transcript expression is suppressed during acquired …