Much of the original research on desmosomes and their biochemical components was
through analysis of skin and mucous membranes. The identification of desmogleins 1 and 3 …

Publisher Summary This chapter focuses on cell adhesion molecules as targets of
autoantibodies in pemphigus and pemphigoid, bullous diseases. In various autoimmune …

Pemphigus vulgaris (PV) is a life-threatening skin disease in which autoantibodies against a
keratinocyte cell surface 130 kd glycoprotein, PV antigen (PVA), cause loss of cell-cell …

We have established, by means of a monoclonal antibody and a cDNA clone, that a
desmosomal polypeptide of M, 83,000 also occurs at the plaques of other types of adhering …

Medium conditioned by human embryo fibroblasts breaks structural junctions between
several types of epithelial cells, leading to separation and scattering of the cells. An assay …

Among sarcomeric muscles the cardiac muscle cells are unique by, inter alia, a systemic
and extended cell–cell contact structure, the intercalated disk (ID), comprising frequent and …

Abstract EPSTEIN–BARR virus (EBV), a human herpesvirus, is strongly linked with two
relatively rare forms of B-cell lymphoma and with a much more prevalent epithelial …

Using antibodies and recombinant DNA techniques, we have identified plakophilin 2, a
novel desmosomal plaque protein of M (r) 100,000 (estimated from SDS-PAGE), which is a …

Four human cell lines were established from biopsy specimens of squamous cell
carcinomas of the larynx (TR131 and TR138), tongue (TR126), and buccal mucosa that had …

We used antibodies raised against individual desmosomal components to study calcium-
induced desmosome formation in human keratinocytes. When keratinocytes are forced to …