The brain is a vital organ, susceptible to alterations under genetic influences and
environmental experiences. Social isolation (SI) acts as a stressor which results in …

Endocannabinoids are key modulators of synaptic function. By activating cannabinoid
receptors expressed in the central nervous system, these lipid messengers can regulate …

Preclinical and clinical studies implicate endocannabinoids (eCBs) in fear extinction, but the
underlying neural circuit basis of these actions is unclear. Here, we employed in vivo …

The discovery of cannabinoid receptors and subsequent identification of their endogenous
ligands (endocannabinoids) in early 1990s have greatly accelerated research on …

Exposure to stress is an undeniable, but in most cases surmountable, part of life. However,
in certain individuals, exposure to severe or cumulative stressors can lead to an array of …

Impairment of working memory is one of the most important deleterious effects of marijuana
intoxication in humans, but its underlying mechanisms are presently unknown. Here, we …

Balanced control of neuronal activity is central in maintaining function and viability of
neuronal circuits. The endocannabinoid system tightly controls neuronal excitability. Here …

The hypothalamic-pituitary-adrenal (HPA) axis regulates the outflow of glucocorticoid
hormones under basal conditions and in response to stress. Within the last decade, a large …

The roles of endocannabinoid signaling during central nervous system development are
unknown. We report that CB1 cannabinoid receptors (CB1Rs) are enriched in the axonal …

The past two decades have witnessed a dramatic accumulation of evidence indicating that
the excitatory amino acid glutamate plays an important role in drug addiction and …