Targeting the amyloid‐β (Aβ) peptide cascade has been at the heart of therapeutic
developments in Alzheimer's disease (AD) research for more than 25 years, yet no …

Transthyretin (TTR) is a tetrameric protein transporting hormones in the plasma and brain,
which has many other activities that have not been fully acknowledged. TTR is a positive …

Transthyretin (TTR), an homotetrameric protein mainly synthesized by the liver and the
choroid plexus, and secreted into the blood and the cerebrospinal fluid, respectively, has …

During biofilm formation, Escherichia coli and other Enterobacteriaceae produce an
extracellular matrix consisting of curli amyloid fibers and cellulose. The precursor of curli …

Seminal studies using post-mortem brains of patients with Alzheimer's disease evidenced
aberrant insulin-like growth factor 1 receptor (IGF1R) signalling. Addressing causality, work …

Human transthyretin (TTR) is a tetrameric protein transporting thyroid hormones and retinol.
TTR is a neuroprotective factor and sensor of oxidative stress which stability is diminished …

Hereditary transthyretin (TTR) amyloidosis associated with the TTRV30M (p. TTRV50M)
mutation presents predominantly as an axonal polyneuropathy, with variable involvement of …

Most eukaryotic secretory proteins are cotranslationally translocated through Sec61 into the
endoplasmic reticulum (ER). Because these proteins have evolved to fold in the ER, their …

Amyloid fibrils are physiologically insoluble biophysically specific β-sheet rich structures
formed by the aggregation of misfolded proteins. In vivo tissue amyloid formation is …

Background: Although several studies have reported an association between thyroid
dysfunction and Alzheimer's disease (AD), the effect of mild thyroid dysfunction within the …