A review of human coronaviruses' receptors: the host-cell targets for the crown bearing viruses

A Nassar, IM Ibrahim, FG Amin, M Magdy, AM Elgharib… - Molecules, 2021 - mdpi.com
A novel human coronavirus prompted considerable worry at the end of the year 2019. Now,
it represents a significant global health and economic burden. The newly emerged …

How helpful were molecular dynamics simulations in shaping our understanding of SARS-CoV-2 spike protein dynamics?

JM Abduljalil, AM Elghareib, A Samir, AA Ezat… - International Journal of …, 2023 - Elsevier
The SARS-CoV-2 spike protein (S) represents an important viral component that is required
for successful viral infection in humans owing to its essential role in recognition of and entry …

Interference of Chaga mushroom terpenoids with the attachment of SARS-CoV-2; in silico perspective

WM Elshemey, AA Elfiky, IM Ibrahim… - Computers in Biology and …, 2022 - Elsevier
Finding a potent inhibitor to the pandemic SARS-CoV-2 is indispensable nowadays.
Currently, in-silico methods work as expeditious investigators to screen drugs for possible …

SARS-CoV-2 delta variant is recognized through GRP78 host-cell surface receptor, in silico perspective

AA Elfiky, IM Ibrahim, AM Elgohary - International Journal of Peptide …, 2022 - Springer
Different SARS-CoV-2 new variants emerged and spread during the past few months,
sparking infections and death counts. The new variant B. 1.617 (delta variant) sparked in …

Dual Targeting of RdRps of SARS-CoV-2 and the Mucormycosis-Causing Fungus: An in silico Perspective

AA Elfiky - Future Microbiology, 2022 - Taylor & Francis
During the past few months, mucormycosis has been associated with SARS-CoV-2
infections. Molecular docking combined with molecular dynamics simulation is utilized to test …

Anti-breast cancer drugs targeting cell-surface glucose-regulated protein 78: a drug repositioning in silico study

A Abu-Mahfouz, M Ali, A Elfiky - Journal of Biomolecular Structure …, 2023 - Taylor & Francis
Breast cancer (BC) is prevalent worldwide and is a leading cause of death among women.
However, cell-surface glucose-regulated protein 78 (cs-GRP78) is overexpressed in several …

[HTML][HTML] Vulnerability of the Male reproductive system to SARS-CoV-2 invasion: potential role for the endoplasmic reticulum chaperone Grp78/HSPA5/BiP

N Sadeghi, M Tavalaee, A Shahverdi… - Cell Journal …, 2022 - ncbi.nlm.nih.gov
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) may adversely affect male
reproductive tissues and male fertility. This concern is elicited by the higher susceptibility …

Cs-GRP78 Recognition Site on Dengue Virus Envelope Protein: in silico perspective

AA Elfiky, A Amr, A Mosaad, AK Mubarak… - Future …, 2023 - Taylor & Francis
Aim: To understand the binding of the dengue virus (DENV) envelope and the host cell
factor, GRP78. Materials & methods: In this study, we simulate the binding of the DENV …

Novel approaches in the management of mucormycosis

F Lamoth - Current Fungal Infection Reports, 2023 - Springer
Abstract Purpose of Review Invasive mucormycosis (IM), caused by fungi of the order
Mucorales, is one of the deadliest fungal infection among hematologic cancer patients. Its …

Structural and functional insights into fungal glutaminase using a computational approach

A Amobonye, S Singh, K Mukherjee, C Jobichen… - Process …, 2022 - Elsevier
Fungal glutaminases are significant among microbial glutaminases due to their current and
potential industrial applications. They have been found useful as food flavoring agents …