Accurate DNA replication and repair is essential for proper development, growth and tumor-
free survival in all multicellular organisms. A key requirement for the maintenance of …

Cancer was recognized as a genetic disease at least four decades ago, with the realization
that the spontaneous mutation rate must increase early in tumorigenesis to account for the …

Long intergenic non-coding RNA-Nucleotide Metabolism Regulator (lincNMR) is a long non-
coding RNA (lncRNA) which is induced in hepatocellular carcinoma. Its depletion invokes a …

Senescence is defined as a stable cell growth arrest. Oncogene-induced senescence (OIS)
occurs when an activated oncogene is expressed in a normal cell. OIS acts as a bona fide …

Cellular metabolism governs the susceptibility of CD4 T cells to HIV-1 infection. Multiple
early post-fusion steps of HIV-1 replication are restricted in resting peripheral blood CD4 T …

Polyamine inhibition for cancer therapy is, conceptually, an attractive approach but has yet
to meet success in the clinical setting. The aryl hydrocarbon receptor (AHR) is the central …

For> 35 yr, we have known that the accuracy of DNA replication is controlled in large part by
the relative concentrations of the 4 canonical deoxyribonucleoside 5′-triphosphates …

Human papillomavirus (HPV) infection is the most important risk factor for cervical cancer
development. In HeLa cell line, the HPV viral genome is integrated at 8q24 in one allele of …

Previous evidence indicates that a number of proteins are able to interact with cognate
mRNAs. These autogenous associations represent important regulatory mechanisms that …

Melanoma is one of the most aggressive types of human cancers, and the mechanisms
underlying melanoma invasive phenotype are not completely understood. Here, we report …