Proto-Oncogenes and Development During the past decade an avalanche of evidence has
implicated proto-oncogenes in the control of cell proliferation. Products of proto-oncogenes …

One of the most significant problems facing developmental biologists who do not work on an
organism with well-developed genetics-and even for some who do-is how to inhibit the …

Cardiomyocytes derived from human embryonic stem (hES) cells potentially offer large
numbers of cells to facilitate repair of the infarcted heart. However, this approach has been …

Factors affecting egg quality are determined by the intrinsic properties of the egg itself and
the environment in which the egg is fertilized and subsequently incubated. Egg quality in fish …

The cytoplasmic focal adhesion protein-tyrosine kinase (FAK) localizes with surface integrin
receptors at sites where cells attach to the extracellular matrix. Increased FAK tyrosine …

The cellular and molecular events regulating the induction and tissue-specific differentiation
of endoderm are central to our understanding of the development and function of many …

Amphibian studies have implicated Wnt signaling in the regulation of mesoderm formation,
although direct evidence is lacking. We have characterized the expression of 12 mammalian …

Abstract Background: Dickkopf-1 (Dkk-1) is a head inducer secreted from the vertebrate
head organizer and induces anterior development by antagonizing Wnt signaling. Although …

The complexity of the events of embryo implantation and placentation is exemplified by the
number and range of cytokines with demonstrated roles in these processes. Disturbance of …

Bone morphogenetic protein (BMP) receptors signal by phosphorylating Smad1, which then
associates with Smad4; this complex moves into the nucleus and activates transcription …