Protocadherins at the crossroad of signaling pathways
A Pancho, T Aerts, MD Mitsogiannis… - Frontiers in Molecular …, 2020 - frontiersin.org
Protocadherins (Pcdhs) are cell adhesion molecules that belong to the cadherin
superfamily, and are subdivided into clustered (cPcdhs) and non-clustered Pcdhs (ncPcdhs) …
superfamily, and are subdivided into clustered (cPcdhs) and non-clustered Pcdhs (ncPcdhs) …
Clustered protocadherins emerge as novel susceptibility loci for mental disorders
The clustered protocadherins (cPcdhs) are a subfamily of type I single-pass transmembrane
cell adhesion molecules predominantly expressed in the brain. Their stochastic and …
cell adhesion molecules predominantly expressed in the brain. Their stochastic and …
γ-Protocadherins control synapse formation and peripheral branching of touch sensory neurons
S Meltzer, KC Boulanger, AM Chirila, E Osei-Asante… - Neuron, 2023 - cell.com
Light touch sensation begins with activation of low-threshold mechanoreceptor (LTMR)
endings in the skin and propagation of their signals to the spinal cord and brainstem. We …
endings in the skin and propagation of their signals to the spinal cord and brainstem. We …
A unique role for Protocadherin γC3 in promoting dendrite arborization through an Axin1-dependent mechanism
DM Steffen, CM Hanes, KM Mah… - Journal of …, 2023 - Soc Neuroscience
The establishment of a functional cerebral cortex depends on the proper execution of
multiple developmental steps, culminating in dendritic and axonal outgrowth and the …
multiple developmental steps, culminating in dendritic and axonal outgrowth and the …
How clustered protocadherin binding specificity is tuned for neuronal self-/nonself-recognition
The stochastic expression of fewer than 60 clustered protocadherin (cPcdh) isoforms
provides diverse identities to individual vertebrate neurons and a molecular basis for self …
provides diverse identities to individual vertebrate neurons and a molecular basis for self …
Clustered gamma-protocadherins regulate cortical interneuron programmed cell death
Cortical function critically depends on inhibitory/excitatory balance. Cortical inhibitory
interneurons (cINs) are born in the ventral forebrain and migrate into cortex, where their …
interneurons (cINs) are born in the ventral forebrain and migrate into cortex, where their …
The γ-protocadherins regulate the survival of GABAergic interneurons during developmental cell death
Inhibitory interneurons integrate into developing circuits in specific ratios and distributions. In
the neocortex, inhibitory network formation occurs concurrently with the apoptotic elimination …
the neocortex, inhibitory network formation occurs concurrently with the apoptotic elimination …
Modifying PCDH19 levels affects cortical interneuron migration
A Pancho, MD Mitsogiannis, T Aerts… - Frontiers in …, 2022 - frontiersin.org
PCDH19 is a transmembrane protein and member of the protocadherin family. It is encoded
by the X-chromosome and more than 200 mutations have been linked to the …
by the X-chromosome and more than 200 mutations have been linked to the …
The γ-protocadherins interact physically and functionally with neuroligin-2 to negatively regulate inhibitory synapse density and are required for normal social …
Cell adhesion molecules (CAMs) are key players in the formation of neural circuits during
development. The γ-protocadherins (γ-Pcdhs), a family of 22 CAMs encoded by the Pcdhg …
development. The γ-protocadherins (γ-Pcdhs), a family of 22 CAMs encoded by the Pcdhg …
A systematic CRISPR screen reveals redundant and specific roles for Dscam1 isoform diversity in neuronal wiring
H Dong, X Yang, L Wu, S Zhang, J Zhang, P Guo… - PLoS …, 2023 - journals.plos.org
Drosophila melanogaster Down syndrome cell adhesion molecule 1 (Dscam1) encodes
19,008 diverse ectodomain isoforms via the alternative splicing of exon 4, 6, and 9 clusters …
19,008 diverse ectodomain isoforms via the alternative splicing of exon 4, 6, and 9 clusters …