Diabetic sensorimotor peripheral neuropathy (DSPN) is a serious complication of diabetes
mellitus and is associated with increased mortality, lower-limb amputations and distressing …

The known seven mammalian receptor subunits (P2X1–7) form cationic channels gated by
ATP. Three subunits compose a receptor channel. Each subunit is a polypeptide consisting …

Neuropathic pain is a frequent condition caused by a lesion or disease of the central or
peripheral somatosensory nervous system. A frequent cause of peripheral neuropathic pain …

ATP is a (co) transmitter and signaling molecule in the CNS. It acts at a multitude of ligand-
gated cationic channels termed P2X to induce rapid depolarization of the cell membrane …

Chronic pain is a maladaptive neurological disease that remains a major health problem. A
deepening of our knowledge on mechanisms that cause pain is a prerequisite to developing …

Chronic low-grade inflammation contributes to the development of several diseases,
including cardiovascular disease. Adequate strategies to target inflammation in …

The first point of our body's contact with tactile stimuli (innocuous and noxious) is the
epidermis, the outermost layer of skin that is largely composed of keratinocytes. Here, we …

Abstract ATP-dependent P2X3 receptors play a crucial role in the sensitization of nerve
fibers and pathological pain pathways. They are also involved in pathways triggering cough …

Inflammatory pain is caused by peripheral tissue injury and inflammation. Inflammation
leads to peripheral sensitization, which may further cause central sensitization, resulting in …

Painful diabetic peripheral neuropathy (PDPN) is present in nearly a quarter of people with
diabetes. It is estimated to affect over 100 million people worldwide. PDPN is associated …