Nonsteroidal anti-inflammatory drugs (NSAIDs) are effective, widely used analgesics. For
the past 2 decades, considerable attention has been focused on their cardiovascular safety …

Prostaglandins are lipid autacoids derived from arachidonic acid. They both sustain
homeostatic functions and mediate pathogenic mechanisms, including the inflammatory …

Chronic inflammation underlies various debilitating disorders including autoimmune,
neurodegenerative, vascular and metabolic diseases as well as cancer, where aberrant …

Chronic inflammation is the basis of various chronic illnesses including cancer and vascular
diseases. However, much has yet to be learned how inflammation becomes chronic …

Background—The selective cyclooxygenase-2 (COX-2) inhibitors and other nonselective
nonsteroidal antiinflammatory drugs (NSAIDs) have been associated with increased …

The Group IV phospholipase A2 family is comprised of six intracellular enzymes commonly
called cytosolic phospholipase A2 (cPLA2) α, cPLA2β, cPLA2γ, cPLA2δ, cPLA2ε and …

Background Accumulating evidence indicates increased cardiovascular risk associated with
nonsteroidal anti-inflammatory drug (NSAID) use, in particular in patients with established …

Activation of the immune system by ANG II contributes to the pathogenesis of hypertension,
and pharmacological suppression of lymphocyte responses can ameliorate hypertensive …

Drugs and antibodies that interrupt vascular endothelial growth factor (VEGF) signaling
pathways improve outcomes in patients with a variety of cancers by inhibiting tumor …

Placebo-controlled trials of nonsteroidal antiinflammatory drugs (NSAIDs) selective for COX-
2 have revealed an enhanced risk for cardiovascular events. COX-2 inhibitors (coxibs) …