[HTML][HTML] Extracellular matrix, regional heterogeneity of the aorta, and aortic aneurysm

S Jana, M Hu, M Shen, Z Kassiri - Experimental & molecular medicine, 2019 - nature.com
Aortic aneurysm is an asymptomatic disease with dire outcomes if undiagnosed. Aortic
aneurysm rupture is a significant cause of death worldwide. To date, surgical repair or …

[HTML][HTML] AAA revisited: a comprehensive review of risk factors, management, and hallmarks of pathogenesis

V Kessler, J Klopf, W Eilenberg, C Neumayer… - Biomedicines, 2022 - mdpi.com
Despite declining incidence and mortality rates in many countries, the abdominal aortic
aneurysm (AAA) continues to represent a life-threatening cardiovascular condition with an …

Abdominal aortic aneurysms

J Anagnostakos, BK Lal - Progress in cardiovascular diseases, 2021 - Elsevier
Abdominal aortic aneurysms (AAA) are prevalent among older adults and can cause
significant morbidity and mortality if not addressed in a timely fashion. Their etiology remains …

Defective autophagy in atherosclerosis: to die or to senesce?

MOJ Grootaert, L Roth, DM Schrijvers… - Oxidative medicine …, 2018 - Wiley Online Library
Autophagy is a subcellular process that plays an important role in the degradation of
proteins and damaged organelles such as mitochondria (a process termed “mitophagy”) via …

The gut microbiome and cardiovascular disease: current knowledge and clinical potential

AF Ahmad, G Dwivedi, F O'Gara… - American Journal …, 2019 - journals.physiology.org
Cardiovascular disease (CVD) is the leading cause of death worldwide. The human body is
populated by a diverse community of microbes, dominated by bacteria, but also including …

Modulation of immune‐inflammatory responses in abdominal aortic aneurysm: Emerging molecular targets

H Li, S Bai, Q Ao, X Wang, X Tian, X Li… - Journal of …, 2018 - Wiley Online Library
Abdominal aortic aneurysm (AAA), a deadly vascular disease in human, is a chronic
degenerative process of the abdominal aorta. In this process, inflammatory responses and …

Pathogenic mechanisms and the potential of drug therapies for aortic aneurysm

B Liu, DJ Granville, J Golledge… - American Journal of …, 2020 - journals.physiology.org
Aortic aneurysm is a permanent focal dilation of the aorta. It is usually an asymptomatic
disease but can lead to sudden death due to aortic rupture. Aortic aneurysm-related …

Hsa_circ_0087352 promotes the inflammatory response of macrophages in abdominal aortic aneurysm by adsorbing hsa-miR-149-5p

X Ma, J Xu, Q Lu, X Feng, J Liu, C Cui… - International …, 2022 - Elsevier
Abdominal aortic aneurysms (AAA) is a common cardiovascular disease with the risk of
rupture. Macrophage depletion can significantly limit the formation of experimental AAA …

[HTML][HTML] Tryptophan catabolism and inflammation: A novel therapeutic target for aortic diseases

T Ramprasath, YM Han, D Zhang, CJ Yu… - Frontiers in …, 2021 - frontiersin.org
Aortic diseases are the primary public health concern. As asymptomatic diseases,
abdominal aortic aneurysm (AAA) and atherosclerosis are associated with high morbidity …

[HTML][HTML] Development of pharmacotherapies for abdominal aortic aneurysms

LM Weaver, CD Loftin, CG Zhan - Biomedicine & Pharmacotherapy, 2022 - Elsevier
The cardiovascular field is still searching for a treatment for abdominal aortic aneurysms
(AAA). This inflammatory disease often goes undiagnosed until a late stage and associated …