The discovery of leptin changed the view of adipose tissue from that of a passive vessel that
stores fat to that of a dynamic endocrine organ that actively regulates behaviour and …

Insulin resistance has long been associated with obesity. More than 40 years ago, Randle
and colleagues postulated that lipids impaired insulin-stimulated glucose use by muscles …

Why a thoroughly updated and revised second edition of this book about theories of disease
distribution, in past and present societal and ecological context? Because the lived realities …

Nutrition has long been considered more the domain of medicine and agriculture than of the
biological sciences, yet it touches and shapes all aspects of the natural world. The need for …

Background: Adaptive thermogenesis (AT) is the fat-free mass (FFM)–independent reduction
of resting energy expenditure (REE) to caloric restriction (CR). AT attenuates weight loss …

The discovery of the archetypal adipocytokine leptin and how it regulates energy
homeostasis have represented breakthroughs in our understanding of the endocrine …

The close correspondence between energy intake and expenditure over prolonged time
periods, coupled with an apparent protection of the level of body adiposity in the face of …

Hypertension affects over 1.2 billion individuals worldwide and has become the most critical
and expensive public health problem. Hypertension is a multifactorial disease involving …

Transcription and translation require a high concentration of potassium across the entire tree
of life. The conservation of a high intracellular potassium was an absolute requirement for …

Weight loss dieting remains the treatment of choice for the vast majority of obese individuals,
despite the limited long-term success of behavioral weight loss interventions. The reasons …