[HTML][HTML] Understanding the habenula: A major node in circuits regulating emotion and motivation
Over the last decade, the understanding of the habenula has rapidly advanced from being
an understudied brain area with the Latin name 'habena” meaning “little rein”, to being …
an understudied brain area with the Latin name 'habena” meaning “little rein”, to being …
Cerebellin–neurexin complexes instructing synapse properties
TC Südhof - Current opinion in neurobiology, 2023 - Elsevier
Abstract Cerebellins (Cbln1-4) are secreted adaptor proteins that connect presynaptic
neurexins (Nrxn1-3) to postsynaptic ligands (GluD1/2 for Cbln1-3 vs. DCC and Neogenin-1 …
neurexins (Nrxn1-3) to postsynaptic ligands (GluD1/2 for Cbln1-3 vs. DCC and Neogenin-1 …
[HTML][HTML] Cell-type-specific population dynamics of diverse reward computations
Computational analysis of cellular activity has developed largely independently of modern
transcriptomic cell typology, but integrating these approaches may be essential for full …
transcriptomic cell typology, but integrating these approaches may be essential for full …
Alternative splicing of presynaptic neurexins differentially controls postsynaptic NMDA and AMPA receptor responses
J Dai, J Aoto, TC Südhof - Neuron, 2019 - cell.com
AMPA-and NMDA-type glutamate receptors mediate distinct postsynaptic signals that differ
characteristically among synapses. How postsynaptic AMPA-and NMDA-receptor levels are …
characteristically among synapses. How postsynaptic AMPA-and NMDA-receptor levels are …
A synthetic synaptic organizer protein restores glutamatergic neuronal circuits
K Suzuki, J Elegheert, I Song, H Sasakura, O Senkov… - Science, 2020 - science.org
INTRODUCTION Synapses are fundamental structural and functional units within neural
circuits, where they define the connectivity between neurons and provide avenues for …
circuits, where they define the connectivity between neurons and provide avenues for …
Latrophilin GPCR signaling mediates synapse formation
R Sando, TC Südhof - Elife, 2021 - elifesciences.org
Neural circuit assembly in the brain requires precise establishment of synaptic connections,
but the mechanisms of synapse assembly remain incompletely understood. Latrophilins are …
but the mechanisms of synapse assembly remain incompletely understood. Latrophilins are …
Proper synaptic adhesion signaling in the control of neural circuit architecture and brain function
Trans-synaptic cell-adhesion molecules are critical for governing various stages of synapse
development and specifying neural circuit properties via the formation of multifarious …
development and specifying neural circuit properties via the formation of multifarious …
Distinct neurexin-cerebellin complexes control AMPA-and NMDA-receptor responses in a circuit-dependent manner
J Dai, K Liakath-Ali, SR Golf, TC Südhof - elife, 2022 - elifesciences.org
At CA1→ subiculum synapses, alternatively spliced neurexin-1 (Nrxn1 SS4+) and neurexin-
3 (Nrxn3 SS4+) enhance NMDA-receptors and suppress AMPA-receptors, respectively …
3 (Nrxn3 SS4+) enhance NMDA-receptors and suppress AMPA-receptors, respectively …
Cerebellin-2 regulates a serotonergic dorsal raphe circuit that controls compulsive behaviors
E Seigneur, J Wang, J Dai, J Polepalli… - Molecular psychiatry, 2021 - nature.com
Abstract Cerebellin-1 (Cbln1) and cerebellin-2 (Cbln2) are secreted glycoproteins that are
expressed in distinct subsets of neurons throughout the brain. Cbln1 and Cbln2 …
expressed in distinct subsets of neurons throughout the brain. Cbln1 and Cbln2 …
Transsynaptic cerebellin 4–neogenin 1 signaling mediates LTP in the mouse dentate gyrus
K Liakath-Ali, JS Polepalli, SJ Lee… - Proceedings of the …, 2022 - National Acad Sciences
Five decades ago, long-term potentiation (LTP) of synaptic transmission was discovered at
entorhinal cortex→ dentate gyrus (EC→ DG) synapses, but the molecular determinants of …
entorhinal cortex→ dentate gyrus (EC→ DG) synapses, but the molecular determinants of …