[HTML][HTML] Understanding the habenula: A major node in circuits regulating emotion and motivation

JL Ables, K Park, I Ibañez–Tallon - Pharmacological research, 2023 - Elsevier
Over the last decade, the understanding of the habenula has rapidly advanced from being
an understudied brain area with the Latin name 'habena” meaning “little rein”, to being …

Cerebellin–neurexin complexes instructing synapse properties

TC Südhof - Current opinion in neurobiology, 2023 - Elsevier
Abstract Cerebellins (Cbln1-4) are secreted adaptor proteins that connect presynaptic
neurexins (Nrxn1-3) to postsynaptic ligands (GluD1/2 for Cbln1-3 vs. DCC and Neogenin-1 …

[HTML][HTML] Cell-type-specific population dynamics of diverse reward computations

EL Sylwestrak, YJ Jo, S Vesuna, X Wang, B Holcomb… - Cell, 2022 - cell.com
Computational analysis of cellular activity has developed largely independently of modern
transcriptomic cell typology, but integrating these approaches may be essential for full …

Alternative splicing of presynaptic neurexins differentially controls postsynaptic NMDA and AMPA receptor responses

J Dai, J Aoto, TC Südhof - Neuron, 2019 - cell.com
AMPA-and NMDA-type glutamate receptors mediate distinct postsynaptic signals that differ
characteristically among synapses. How postsynaptic AMPA-and NMDA-receptor levels are …

A synthetic synaptic organizer protein restores glutamatergic neuronal circuits

K Suzuki, J Elegheert, I Song, H Sasakura, O Senkov… - Science, 2020 - science.org
INTRODUCTION Synapses are fundamental structural and functional units within neural
circuits, where they define the connectivity between neurons and provide avenues for …

Latrophilin GPCR signaling mediates synapse formation

R Sando, TC Südhof - Elife, 2021 - elifesciences.org
Neural circuit assembly in the brain requires precise establishment of synaptic connections,
but the mechanisms of synapse assembly remain incompletely understood. Latrophilins are …

Proper synaptic adhesion signaling in the control of neural circuit architecture and brain function

HY Kim, JW Um, J Ko - Progress in Neurobiology, 2021 - Elsevier
Trans-synaptic cell-adhesion molecules are critical for governing various stages of synapse
development and specifying neural circuit properties via the formation of multifarious …

Distinct neurexin-cerebellin complexes control AMPA-and NMDA-receptor responses in a circuit-dependent manner

J Dai, K Liakath-Ali, SR Golf, TC Südhof - elife, 2022 - elifesciences.org
At CA1→ subiculum synapses, alternatively spliced neurexin-1 (Nrxn1 SS4+) and neurexin-
3 (Nrxn3 SS4+) enhance NMDA-receptors and suppress AMPA-receptors, respectively …

Cerebellin-2 regulates a serotonergic dorsal raphe circuit that controls compulsive behaviors

E Seigneur, J Wang, J Dai, J Polepalli… - Molecular psychiatry, 2021 - nature.com
Abstract Cerebellin-1 (Cbln1) and cerebellin-2 (Cbln2) are secreted glycoproteins that are
expressed in distinct subsets of neurons throughout the brain. Cbln1 and Cbln2 …

Transsynaptic cerebellin 4–neogenin 1 signaling mediates LTP in the mouse dentate gyrus

K Liakath-Ali, JS Polepalli, SJ Lee… - Proceedings of the …, 2022 - National Acad Sciences
Five decades ago, long-term potentiation (LTP) of synaptic transmission was discovered at
entorhinal cortex→ dentate gyrus (EC→ DG) synapses, but the molecular determinants of …