Aging is characterized by a progressive deterioration of physiological integrity, leading to
impaired functional ability and ultimately increased susceptibility to death. It is a major risk …

Over time, the human DNA methylation landscape accrues substantial damage, which has
been associated with a broad range of age-related diseases, including cardiovascular …

Immunosenescence is a process of immune dysfunction that occurs with age and includes
remodeling of lymphoid organs, leading to changes in the immune function of the elderly …

The skin is the largest organ and has a key protective role. Similar to any other tissue, the
skin is influenced not only by intrinsic/chronological aging, but also by extrinsic aging …

With the ageing of the global population, interest is growing in the 'geroscience hypothesis',
which posits that manipulation of fundamental ageing mechanisms will delay (in parallel) the …

Although death is inevitable, individuals have long sought to alter the course of the ageing
process. Indeed, ageing has proved to be modifiable; by intervening in biological systems …

Inhibition of the protein kinase mechanistic target of rapamycin (mTOR) with the Food and
Drug Administration (FDA)-approved therapeutic rapamycin promotes health and longevity …

Cellular senescence entails essentially irreversible replicative arrest, apoptosis resistance,
and frequently acquisition of a pro-inflammatory, tissue-destructive senescence-associated …

Aging has been targeted by genetic and dietary manipulation and by drugs in order to
increase lifespan and health span in numerous models. Metformin, which has demonstrated …

Since the late 18th century, the murine model has been widely used in biomedical research
(about 59% of total animals used) as it is compact, cost-effective, and easily available …