In the last decade, the role of apoptosis in the pathophysiology of acute kidney injury (AKI)
and AKI to chronic kidney disease (CKD) progression has been revisited as our …

The physiological process of biomineralization is complex and deviation from it leads to a
variety of diseases. Progress in the past 10 years has enhanced understanding of the …

Crystals can trigger a wide range of kidney injuries that can lead to acute kidney injury,
chronic kidney disease, renal colic or nephrocalcinosis, depending on the localization and …

Background Polarized macrophage populations can orchestrate both inflammation of the
kidney and tissue repair during CKD. Proinflammatory M1 macrophages initiate kidney …

Primary hyperoxalurias are a devastating family of diseases leading to multisystem oxalate
deposition, nephrolithiasis, nephrocalcinosis and end-stage renal disease. Traditional …

Necrosis is a hallmark of several widespread diseases or their direct complications. In the
past decade, we learned that necrosis can be a regulated process that is potentially …

Calcium oxalate (CaOx) stones are among the most common types of kidney stones and are
associated with renal tubular damage, interstitial fibrosis, and chronic kidney disease. The …

Over-accumulation of oxalate in humans may lead to nephrolithiasis and nephrocalcinosis.
Humans lack endogenous oxalate degradation pathways (ODP), but intestinal microbes can …

Abstract Ethnopharmacological relevance Traditional Chinese medicine provides a unique
curative treatment of complex chronic diseases, including chronic kidney disease (CKD) …

Background: The entity of crystal nephropathies encompasses a spectrum of different kidney
injuries induced by crystal-formed intrinsic minerals, metabolites, and proteins or extrinsic …