Crystallography supplies unparalleled detail on structural information critical for mechanistic
analyses; however, it is restricted to describing low energy conformations of …

Technical advances on several frontiers have expanded the applicability of existing methods
in structural biology and helped close the resolution gaps between them. As a result, we are …

Model building into experimental maps is a key element of structural biology, but can be
both time consuming and error prone for low-resolution maps. Here we present Namdinator …

Introduction Bacteria and archaea defend themselves against invasive DNA using adaptive
immune systems comprising CRISPR (clustered regularly interspaced short palindromic …

Cryoelectron microscopy of biological molecules is among the hottest growth areas in
biophysics and structural biology at present, and Frank is arguably the most distinguished …

Plasmodium vivax shows a strict host tropism for reticulocytes. We identified transferrin
receptor 1 (TfR1) as the receptor for P. vivax reticulocyte-binding protein 2b (PvRBP2b). We …

We describe methods for interactive visualization and analysis of density maps available in
the UCSF Chimera molecular modeling package. The methods enable segmentation, fitting …

Robust innate immune detection of rapidly evolving pathogens is critical for host defense.
Nucleotide-binding domain leucine-rich repeat (NLR) proteins function as cytosolic innate …

Cryo-electron microscopy produces 3D density maps of molecular machines, which consist
of various molecular components such as proteins and RNA. Segmentation of individual …

Synaptic vesicles are organelles with a precisely defined protein and lipid composition,, yet
the molecular mechanisms for the biogenesis of synaptic vesicles are mainly unknown. Here …