Therapeutic targeting of the hypoxic tumour microenvironment

DC Singleton, A Macann, WR Wilson - Nature reviews Clinical oncology, 2021 - nature.com
Hypoxia is prevalent in human tumours and contributes to microenvironments that shape
cancer evolution and adversely affect therapeutic outcomes. Historically, two different …

Radiotherapy toxicity

D De Ruysscher, G Niedermann, NG Burnet… - Nature Reviews …, 2019 - nature.com
Radiotherapy is used in> 50% of patients with cancer, both for curative and palliative
purposes. Radiotherapy uses ionizing radiation to target and kill tumour tissue, but normal …

Phase 3 multi-center, prospective, randomized trial comparing single-dose 24 Gy radiation therapy to a 3-fraction SBRT regimen in the treatment of oligometastatic …

MJ Zelefsky, Y Yamada, C Greco, E Lis… - International Journal of …, 2021 - Elsevier
Purpose This prospective phase 3 randomized trial was designed to test whether ultra high
single-dose radiation therapy (24 Gy SDRT) improves local control of oligometastatic lesions …

The technical and clinical implementation of LATTICE radiation therapy (LRT)

X Wu, NC Perez, Y Zheng, X Li, L Jiang… - Radiation …, 2020 - meridian.allenpress.com
The concept of spatially fractionated radiation therapy (SFRT) was conceived over 100 years
ago, first in the form of GRID, which has been applied to clinical practice since its early …

Safety and efficacy of virtual prostatectomy with single-dose radiotherapy in patients with intermediate-risk prostate cancer: results from the PROSINT phase 2 …

C Greco, O Pares, N Pimentel, V Louro… - JAMA …, 2021 - jamanetwork.com
Importance Ultra-high single-dose radiotherapy (SDRT) represents a potential alternative to
curative extreme hypofractionated stereotactic body radiotherapy (SBRT) in organ-confined …

Application of ultrasound combined with microbubbles for cancer therapy

D Sharma, KX Leong, GJ Czarnota - International Journal of Molecular …, 2022 - mdpi.com
At present, cancer is one of the leading causes of death worldwide. Treatment failure
remains one of the prime hurdles in cancer treatment due to the metastatic nature of cancer …

Essential concepts for the management of metastatic spine disease: what the surgeon should know and practice

O Barzilai, S Boriani, CG Fisher, A Sahgal… - Global spine …, 2019 - journals.sagepub.com
Study Design: Literature review. Objective: To provide an overview of the recent advances in
spinal oncology, emphasizing the key role of the surgeon in the treatment of patients with …

Targeting radiation-tolerant persister cells as a strategy for inhibiting radioresistance and recurrence in glioblastoma

J Gu, N Mu, B Jia, Q Guo, L Pan, M Zhu… - Neuro …, 2022 - academic.oup.com
Background Compelling evidence suggests that glioblastoma (GBM) recurrence results from
the expansion of a subset of tumor cells with robust intrinsic or therapy-induced …

Targeting sphingolipid metabolism as a therapeutic strategy in cancer treatment

AH Janneh, B Ogretmen - Cancers, 2022 - mdpi.com
Simple Summary Sphingolipids, which are important cell membrane components, have
critical roles in regulating cancer cell signaling to control pro-tumoral or antitumoral …

[HTML][HTML] Novel unconventional radiotherapy techniques: Current status and future perspectives–Report from the 2nd international radiation oncology online seminar

S Tubin, MC Vozenin, Y Prezado, M Durante… - Clinical and …, 2023 - Elsevier
Novel unconventional radiotherapy techniques: Current status and future perspectives –
Report from the 2nd international radiation oncology online seminar - ScienceDirect Skip to …