The development and life-time of multicellular eukaryotic organisms represents a complex
interplay of numerous pro-liferation and differentiation events that proceed in a highly …

A fundamental question in signal transduction is how stimulation of a specific protein kinase
leads to phosphorylation of particular protein substrates throughout the cell. Recent studies …

We demonstrate that members of the erk-encoded family of mitogen-activated protein (MAP)
kinases (pp44/42 mapk/erk) and members of the rsk-encoded protein kinases (RSKs or …

Protein kinase C (PKC) comprises a family of serine/threonine kinases that are involved in
the transduction of signals for cell proliferation, differentiation, apoptosis and angiogenesis …

Phosphorylation of Bcl2 at serine 70 may result from activation of a classic protein kinase C
(PKC) isoform and is required for functional suppression of apoptosis by Bcl2 in murine …

During the past twenty years, evidence has accumulated for the presence of phospholipids
within the nuclei of eukaryotic cells. These phospholipids are distinct from those that are …

Current cancer therapies are highly toxic and often nonspecific. A potentially less toxic
approach to treating this prevalent disease employs agents that modify cancer cell …

Nuclear protein transport is integral to eukaryotic cell processes such as differentiation,
transformation, and the control of gene expression. Although the targeting role of nuclear …

Spatial and temporal organization of signal transduction is essential in determining the
speed and precision by which signaling events occur. Adaptor proteins are key to organizing …

Protein kinase C (PKC) plays a central role in the control of proliferation and differentiation of
a wide range of cell types by mediating the signal transduction response to hormones and …