Transfer learning enables predictions in network biology
Mapping gene networks requires large amounts of transcriptomic data to learn the
connections between genes, which impedes discoveries in settings with limited data …
connections between genes, which impedes discoveries in settings with limited data …
Single-cell multi-omics analysis of the immune response in COVID-19
Abstract Analysis of human blood immune cells provides insights into the coordinated
response to viral infections such as severe acute respiratory syndrome coronavirus 2, which …
response to viral infections such as severe acute respiratory syndrome coronavirus 2, which …
Mapping the developing human immune system across organs
Single-cell genomics studies have decoded the immune cell composition of several human
prenatal organs but were limited in describing the developing immune system as a …
prenatal organs but were limited in describing the developing immune system as a …
[HTML][HTML] Hematopoietic stem and progenitor cells outside the bone marrow: where, when, and why
N Mende, E Laurenti - Experimental hematology, 2021 - Elsevier
Highlights•Rare HSPCs are found in blood and tissues such as spleen, liver, and
lung.•Extramedullary HSPCs contribute to blood formation under stress conditions.•The …
lung.•Extramedullary HSPCs contribute to blood formation under stress conditions.•The …
Hypoxia activates SREBP2 through Golgi disassembly in bone marrow‐derived monocytes for enhanced tumor growth
R Nakahara, S Aki, M Sugaya, H Hirose, M Kato… - The EMBO …, 2023 - embopress.org
Bone marrow‐derived cells (BMDCs) infiltrate hypoxic tumors at a pre‐angiogenic state and
differentiate into mature macrophages, thereby inducing pro‐tumorigenic immunity. A critical …
differentiate into mature macrophages, thereby inducing pro‐tumorigenic immunity. A critical …
Hematopoietic differentiation is characterized by a transient peak of entropy at a single-cell level
C Dussiau, A Boussaroque, M Gaillard, C Bravetti… - BMC biology, 2022 - Springer
Background Mature blood cells arise from hematopoietic stem cells in the bone marrow by a
process of differentiation along one of several different lineage trajectories. This is often …
process of differentiation along one of several different lineage trajectories. This is often …
The cellular immune response to COVID-19 deciphered by single cell multi-omics across three UK centres
The COVID-19 pandemic, caused by SARS coronavirus 2 (SARS-CoV-2), has resulted in
excess morbidity and mortality as well as economic decline. To characterise the systemic …
excess morbidity and mortality as well as economic decline. To characterise the systemic …
Stem cell-based disease models for inborn errors of immunity
The intrinsic capacity of human hematopoietic stem cells (hHSCs) to reconstitute myeloid
and lymphoid lineages combined with their self-renewal capacity hold enormous promises …
and lymphoid lineages combined with their self-renewal capacity hold enormous promises …
Mapping the biogenesis of forward programmed megakaryocytes from induced pluripotent stem cells
Platelet deficiency, known as thrombocytopenia, can cause hemorrhage and is treated with
platelet transfusions. We developed a system for the production of platelet precursor cells …
platelet transfusions. We developed a system for the production of platelet precursor cells …
Learning processes in hierarchical pairs regulate entire gene expression in cells
T Yamaguchi - Scientific Reports, 2022 - nature.com
Expression of numerous genes is precisely controlled in a cell in various contexts. While
genetic and epigenetic mechanisms contribute to this regulation, how each mechanism …
genetic and epigenetic mechanisms contribute to this regulation, how each mechanism …