Abstract The coronavirus disease 2019 (COVID-19) pandemic has stimulated tremendous
efforts to develop therapeutic strategies that target severe acute respiratory syndrome …

The zoonotic emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
and the ensuing coronavirus disease 2019 (COVID-19) pandemic have profoundly affected …

Decoration of cap on viral RNA plays essential roles in SARS-CoV-2 proliferation. Here, we
report a mechanism for SARS-CoV-2 RNA capping and document structural details at …

Abstract The SARS-CoV-2 RNA-dependent RNA polymerase coordinates viral RNA
synthesis as part of an assembly known as the replication–transcription complex (RTC) …

Regulation of viral RNA biogenesis is fundamental to productive SARS-CoV-2 infection. To
characterize host RNA-binding proteins (RBPs) involved in this process, we biochemically …

Abstract The coronavirus disease 2019 (COVID-19) caused by coronavirus SARS-CoV-2
infection has become a global pandemic due to the high viral transmissibility and …

Nucleoside/tide analogues (NAs) have long been used in the fight against viral diseases,
and now present a promising option for the treatment of COVID-19. Once activated to the 5 …

Recent advances in protein structure prediction have generated accurate structures of
previously uncharacterized human proteins. Identifying domains in these predicted …

Coronaviruses are a group of related RNA viruses that cause respiratory diseases in
humans and animals. Understanding the mechanisms of translation regulation during …

Re-emerging and new viral pathogens have caused significant morbidity and mortality
around the world, as evidenced by the recent monkeypox, Ebola and Zika virus outbreaks …