Proteomic signatures of physical, cognitive, and imaging outcomes in multiple sclerosis
Background A quantitative measurement of serum proteome biomarkers that would
associate with disease progression endpoints can provide risk stratification for persons with …
associate with disease progression endpoints can provide risk stratification for persons with …
Inflammatory and neurodegenerative serum protein biomarkers increase sensitivity to detect clinical and radiographic disease activity in multiple sclerosis
The multifaceted nature of multiple sclerosis requires quantitative biomarkers that can
provide insights related to diverse physiological pathways. To this end, proteomic analysis of …
provide insights related to diverse physiological pathways. To this end, proteomic analysis of …
Association between serum multi-protein biomarker profile and real-world disability in multiple sclerosis
W Zhu, C Chen, L Zhang, T Hoyt, E Walker… - Brain …, 2024 - academic.oup.com
Few studies examined blood biomarkers informative of patient-reported outcome (PRO) of
disability in people with multiple sclerosis (MS). We examined the associations between …
disability in people with multiple sclerosis (MS). We examined the associations between …
Lower arterial cerebral blood flow is associated with worse neuroinflammation and immunomodulation composite proteomic scores
D Jakimovski, F Qureshi, M Ramanathan… - Multiple Sclerosis and …, 2024 - Elsevier
Background Brain hypoperfusion is linked with worse physical, cognitive and MRI outcomes
in multiple sclerosis (MS). Understanding the proteomic signatures related to hypoperfusion …
in multiple sclerosis (MS). Understanding the proteomic signatures related to hypoperfusion …
[HTML][HTML] Assessment of the concomitant action of XBD173 and interferon β in a mouse model of multiple sclerosis using infrared marker bands
K Sirinukunwattana, C Klein, PFA Clarke… - … Acta Part A: Molecular …, 2025 - Elsevier
Disease modifying therapies including interferon-β (IFNβ) effectively counteract the
inflammatory component in relapsing-remitting multiple sclerosis (RRMS) but this action …
inflammatory component in relapsing-remitting multiple sclerosis (RRMS) but this action …
Glial cell injury and atrophied lesion volume as measures of chronic multiple sclerosis inflammation
D Jakimovski, F Qureshi, M Ramanathan… - Journal of the …, 2024 - Elsevier
Background Atrophied lesion volume (aLV), a proposed biomarker of disability progression
in multiple sclerosis (MS) and transition into progressive MS (PMS), depicts chronic …
in multiple sclerosis (MS) and transition into progressive MS (PMS), depicts chronic …