Major depressive disorder is a debilitating mental illness and a leading cause of global
disease burden. While many etiological factors have been identified, social stress is a highly …

Background Metformin, a first-line antiglycemic drug, has been reported to have anti-
depressant effects in patients with type 2 diabetes; however, its exact role and underlying …

Depression is a severe and debilitating mental disorder diagnosed by evaluation of
affective, cognitive and physical depression symptoms. Severity of these symptoms strongly …

Social anxiety disorder (SAD) is a psychiatric disorder characterized by extensive fear in
social situations. Multiple genetic and environmental factors are known to contribute to its …

Background Development of anxiety-and depression-like states under chronic social defeat
stress in mice has been shown by many experimental studies. In this article, the differentially …

There is experimental evidence that chronic social defeat stress is accompanied by the
development of an anxiety, development of a depression-like state, and downregulation of …

Icariin (ICA) has a significant capacity to protect against depression and hippocampal injury,
but it cannot effectively cross the blood-brain barrier and accumulate in the brain. Therefore …

One of the new theories accounting for the underlying pathophysiology of schizophrenia is
excitation/inhibition imbalance. Interestingly, perturbation in protein synthesis machinery as …

Most neurological disorders are caused by abnormal gene translation. Generally,
dysregulation of elements involved in the translational process disrupts homeostasis in …

Although major depressive disorder (MDD) is a leading cause of disability worldwide, its
pathophysiology is poorly understood. Increasing evidence suggests that aberrant …