Targeted regulated cell death with small molecule compounds in colorectal cancer: Current perspectives of targeted therapy and molecular mechanisms
R Li, Y Wu, Y Li, W Shuai, A Wang, Y Zhu, X Hu… - European Journal of …, 2024 - Elsevier
Colorectal cancer (CRC), a tumor of the digestive system, is characterized by high
malignancy and poor prognosis. Currently, targeted therapy of CRC is far away from …
malignancy and poor prognosis. Currently, targeted therapy of CRC is far away from …
A cellular and molecular biology-based update for ivermectin against COVID-19: is it effective or non-effective?
M Nabi-Afjadi, F Mohebi, H Zalpoor, F Aziziyan… - …, 2023 - Springer
Despite community vaccination against coronavirus disease 2019 (COVID-19) and reduced
mortality, there are still challenges in treatment options for the disease. Due to the …
mortality, there are still challenges in treatment options for the disease. Due to the …
Drug induced mitochondria dysfunction to enhance photodynamic therapy of hypoxic tumors
Y Cen, X Chen, Y Liu, B Yu, M Yan, N Yang… - Journal of Controlled …, 2023 - Elsevier
As most solid tumors are characterized by a hypoxic microenvironment, enormous efforts
have been made to develop strategies to fight hypoxia. This study shows that ivermectin …
have been made to develop strategies to fight hypoxia. This study shows that ivermectin …
[HTML][HTML] Oxidative stress and COVID-19-associated neuronal dysfunction: mechanisms and therapeutic implications: SARS-CoV-2 (COVID-19)-mediated oxidative …
Severe acute respiratory syndrome (SARS)-CoV-2 virus causes novel coronavirus disease
2019 (COVID-19), and there is a possible role for oxidative stress in the pathophysiology of …
2019 (COVID-19), and there is a possible role for oxidative stress in the pathophysiology of …
Ivermectin and gemcitabine combination treatment induces apoptosis of pancreatic cancer cells via mitochondrial dysfunction
DE Lee, HW Kang, SY Kim, MJ Kim… - Frontiers in …, 2022 - frontiersin.org
Pancreatic cancer is an aggressive cancer characterized by high mortality and poor
prognosis, with a survival rate of less than 5 years in advanced stages. Ivermectin, an …
prognosis, with a survival rate of less than 5 years in advanced stages. Ivermectin, an …
Oxidative stress-induced cytotoxicity of HCC2998 colon carcinoma cells by ZnO nanoparticles synthesized from Calophyllum teysmannii
The field of green synthesis, namely using plant extracts for the production of metal
nanoparticles, is rapidly gaining traction. Therefore, this study investigated the process of …
nanoparticles, is rapidly gaining traction. Therefore, this study investigated the process of …
Current trends and future prospects of drug repositioning in gastrointestinal oncology
Gastrointestinal (GI) cancers comprise a significant number of cancer cases worldwide and
contribute to a high percentage of cancer-related deaths. To improve survival rates of GI …
contribute to a high percentage of cancer-related deaths. To improve survival rates of GI …
Ivermectin-induced apoptotic cell death in human SH-SY5Y cells involves the activation of oxidative stress and mitochondrial pathway and Akt/mTOR-pathway …
Y Zhang, T Sun, M Li, Y Lin, Y Liu, S Tang, C Dai - Antioxidants, 2022 - mdpi.com
Ivermectin (IVM) could cause potential neurotoxicity; however, the precise molecular
mechanisms remain unclear. This study explores the cytotoxicity of IVM in human …
mechanisms remain unclear. This study explores the cytotoxicity of IVM in human …
[HTML][HTML] Ivermectin contributes to attenuating the severity of acute lung injury in mice
Y Ma, X Xu, H Wu, C Li, P Zhong, Z Liu, C Ma… - Biomedicine & …, 2022 - Elsevier
Ivermectin has been proposed as a potential anti-inflammatory drug in addition to its
antiparasitic activity. Here we investigated the potential role of ivermectin in the …
antiparasitic activity. Here we investigated the potential role of ivermectin in the …
Characterization and protective effect against ultraviolet radiation of a novel exopolysaccharide from Bacillus marcorestinctum QDR3-1
F Li, X Hu, L Qin, H Li, Y Yang, X Zhang, J Lu… - International Journal of …, 2022 - Elsevier
Although exopolysaccharide (EPS) has been applied to various fields, EPS for UVR-
mediated oxidative stress repair still needs further exploration. In this study, a novel EPS …
mediated oxidative stress repair still needs further exploration. In this study, a novel EPS …