Imaging has played a variety of roles in the study of Alzheimer disease (AD) over the past
four decades. Initially, computed tomography (CT) and then magnetic resonance imaging …

Objective: in an effort to enhance medication prescribing for older adults and reduce the
burden of cognitive impairment, this paper reviews the literature regarding the negative …

The hallmark clinical symptom of early Alzheimer's disease (AD) is episodic memory
impairment. Recent functional imaging studies suggest that memory function is subserved …

Objective: To use fMRI to investigate whether hippocampal and entorhinal activation during
learning is altered in the earliest phase of mild cognitive impairment (MCI). Methods: Three …

The ability to detect and respond to novel events is crucial for survival in a rapidly changing
environment. Four decades of neuroscientific research has begun to delineate the neural …

Memory function is likely subserved by multiple distributed neural networks, which are
disrupted by the pathophysiological process of Alzheimer's disease (AD). In this study, we …

Objective To assess the potential of anticholinergic drugs as a cause of non-degenerative
mild cognitive impairment in elderly people. Design Longitudinal cohort study. Setting 63 …

Historically, ACh has been implicated in learning and short-term memory functions.
However, more recent studies have provided support for a role of cortical ACh in attentional …

Neurovascular dysfunction, including blood–brain barrier (BBB) breakdown and cerebral
blood flow (CBF) dysregulation and reduction, are increasingly recognized to contribute to …

Drugs with anticholinergic action are widely prescribed in the elderly population due to their
potential clinical benefits. However, these benefits are limited by adverse effects which may …