Recombination is a pervasive process generating diversity in most viruses. It joins variants
that arise independently within the same molecule, creating new opportunities for viruses to …

Globally, human immunodeficiency virus–type 1 (HIV-1) is extraordinarily variable, and this
diversity poses a major obstacle to AIDS vaccine development. Currently, candidate …

Induction of broadly cross-reactive neutralizing antibodies is a high priority for AIDS vaccine
development but one that has proven difficult to be achieved. While most immunogens …

Within-patient HIV evolution reflects the strong selection pressure driving viral escape from
cytotoxic T-lymphocyte (CTL) recognition. Whether this intrapatient accumulation of escape …

Objectives: We wished to assess the potential of using HIV-1 pol gene for the identification of
transmissions events by phylogenetic means in the era of antiretroviral drug selective …

Genetic variation of human immunodeficiency virus (HIV-1) represents a major obstacle for
AIDS vaccine development. To decrease the genetic distances between candidate …

An understanding of the relationship between the breadth and magnitude of T-cell epitope
responses and viral loads is important for the design of effective vaccines. For this study, we …

Human immunodeficiency virus type 1 (HIV-1)-associated dementia (HAD) is correlated with
increased monocyte migration to the brain, and the incidence of HAD among otherwise …

The review by B. Gaschen et al.(” Diversity considerations in HIV-1 vaccine selection,” 28
June, p. 2354) describes two computational methods (consensus and ancestral state) being …

The devastating consequences of AIDS pandemic will probably only be controlled when a
vaccine is developed that is safe, effective, affordable, and simple enough to permit …