Analyzing high-dimensional cytometry data using FlowSOM
The dimensionality of cytometry data has strongly increased in the last decade, and in many
situations the traditional manual downstream analysis becomes insufficient. The field is …
situations the traditional manual downstream analysis becomes insufficient. The field is …
[HTML][HTML] HIV–host cell interactions
SK Masenga, BC Mweene, E Luwaya, L Muchaili… - Cells, 2023 - mdpi.com
The development of antiretroviral drugs (ARVs) was a great milestone in the management of
HIV infection. ARVs suppress viral activity in the host cell, thus minimizing injury to the cells …
HIV infection. ARVs suppress viral activity in the host cell, thus minimizing injury to the cells …
[HTML][HTML] Limited cross-variant immunity from SARS-CoV-2 Omicron without vaccination
Abstract SARS-CoV-2 Delta and Omicron are globally relevant variants of concern. Although
individuals infected with Delta are at risk of developing severe lung disease, infection with …
individuals infected with Delta are at risk of developing severe lung disease, infection with …
[HTML][HTML] SARS-CoV-2-specific T cells exhibit phenotypic features of helper function, lack of terminal differentiation, and high proliferation potential
Summary Convalescing coronavirus disease 2019 (COVID-19) patients mount robust T cell
responses against SARS-CoV-2, suggesting an important role of T cells in viral clearance …
responses against SARS-CoV-2, suggesting an important role of T cells in viral clearance …
[HTML][HTML] Distinctive features of SARS-CoV-2-specific T cells predict recovery from severe COVID-19
J Neidleman, X Luo, AF George, M McGregor, J Yang… - Cell Reports, 2021 - cell.com
Although T cells are likely players in severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) immunity, little is known about the phenotypic features of SARS-CoV-2 …
(SARS-CoV-2) immunity, little is known about the phenotypic features of SARS-CoV-2 …
[HTML][HTML] mRNA vaccine-induced T cells respond identically to SARS-CoV-2 variants of concern but differ in longevity and homing properties depending on prior …
While mRNA vaccines are proving highly efficacious against SARS-CoV-2, it is important to
determine how booster doses and prior infection influence the immune defense they elicit …
determine how booster doses and prior infection influence the immune defense they elicit …
[HTML][HTML] Phenotypic analysis of the unstimulated in vivo HIV CD4 T cell reservoir
The latent reservoir is a major barrier to HIV cure. As latently infected cells cannot be
phenotyped directly, the features of the in vivo reservoir have remained elusive. Here, we …
phenotyped directly, the features of the in vivo reservoir have remained elusive. Here, we …
Single-cell glycomics analysis by CyTOF-Lec reveals glycan features defining cells differentially susceptible to HIV
High-parameter single-cell phenotyping has enabled in-depth classification and
interrogation of immune cells, but to date has not allowed for glycan characterization. Here …
interrogation of immune cells, but to date has not allowed for glycan characterization. Here …
Endometrial responses to bacterial and viral infection: a scoping review
CV Lindsay, JA Potter, AA Grimshaw… - Human …, 2023 - academic.oup.com
BACKGROUND The endometrium is a highly dynamic tissue that undergoes dramatic
proliferation and differentiation monthly in order to prepare the uterus for implantation and …
proliferation and differentiation monthly in order to prepare the uterus for implantation and …
[HTML][HTML] Deep immunophenotyping reveals endometriosis is marked by dysregulation of the mononuclear phagocytic system in endometrium and peripheral blood
J Vallvé-Juanico, AF George, S Sen, R Thomas… - BMC medicine, 2022 - Springer
Background Endometriosis is a chronic, estrogen-dependent disorder where inflammation
contributes to disease-associated symptoms of pelvic pain and infertility. Immune …
contributes to disease-associated symptoms of pelvic pain and infertility. Immune …