RNA therapeutics: updates and future potential

C Zhang, B Zhang - Science China Life Sciences, 2023 - Springer
Recent advancements in the production, modification, and cellular delivery of RNA
molecules facilitated the expansion of RNA-based therapeutics. The increasing …

RNA structural dynamics as captured by molecular simulations: a comprehensive overview

J Sponer, G Bussi, M Krepl, P Banáš, S Bottaro… - Chemical …, 2018 - ACS Publications
With both catalytic and genetic functions, ribonucleic acid (RNA) is perhaps the most
pluripotent chemical species in molecular biology, and its functions are intimately linked to …

When will RNA get its AlphaFold moment?

B Schneider, BA Sweeney, A Bateman… - Nucleic Acids …, 2023 - academic.oup.com
The protein structure prediction problem has been solved for many types of proteins by
AlphaFold. Recently, there has been considerable excitement to build off the success of …

[HTML][HTML] The noncoding RNA revolution—trashing old rules to forge new ones

TR Cech, JA Steitz - Cell, 2014 - cell.com
Noncoding RNAs (ncRNAs) accomplish a remarkable variety of biological functions. They
regulate gene expression at the levels of transcription, RNA processing, and translation …

Self-assembling nucleic acid nanostructures functionalized with aptamers

A Krissanaprasit, CM Key, S Pontula… - Chemical …, 2021 - ACS Publications
Researchers have worked for many decades to master the rules of biomolecular design that
would allow artificial biopolymer complexes to self-assemble and function similarly to the …

The resolution revolution

W Kühlbrandt - Science, 2014 - science.org
Precise knowledge of the structure of macromolecules in the cell is essential for
understanding how they function. Structures of large macromolecules can now be obtained …

A new system for naming ribosomal proteins

N Ban, R Beckmann, JHD Cate, JD Dinman… - Current opinion in …, 2014 - Elsevier
A system for naming ribosomal proteins is described that the authors intend to use in the
future. They urge others to adopt it. The objective is to eliminate the confusion caused by the …

The structure of the eukaryotic ribosome at 3.0 Å resolution

A Ben-Shem, N Garreau de Loubresse, S Melnikov… - Science, 2011 - science.org
Ribosomes translate genetic information encoded by messenger RNA into proteins. Many
aspects of translation and its regulation are specific to eukaryotes, whose ribosomes are …

Electrostatics of nanosystems: application to microtubules and the ribosome

NA Baker, D Sept, S Joseph, MJ Holst… - Proceedings of the …, 2001 - National Acad Sciences
Evaluation of the electrostatic properties of biomolecules has become a standard practice in
molecular biophysics. Foremost among the models used to elucidate the electrostatic …

RNAmmer: consistent and rapid annotation of ribosomal RNA genes

K Lagesen, P Hallin, EA Rødland… - Nucleic acids …, 2007 - academic.oup.com
The publication of a complete genome sequence is usually accompanied by annotations of
its genes. In contrast to protein coding genes, genes for ribosomal RNA (rRNA) are often …