It is hypothesized that glucokinase (GCK) is the glucose sensor not only for regulation of
insulin release by pancreatic β-cells, but also for the rest of the cells that contribute to …

During the past 30 yr, investigating the physiology of eating behaviors has generated a truly
vast literature. This is fueled in part by a dramatic increase in obesity and its comorbidities …

Although the gastrointestinal (GI) tract possesses intrinsic neural plexuses that allow a
significant degree of autonomy over GI functions, the central nervous system (CNS) provides …

Although the brain has been considered an insulin-insensitive organ, recent reports on the
location of insulin and its receptors in the brain have introduced new ways of considering …

Teleost fishes represent a highly diverse group consisting of more than 20,000 species
living across all aquatic environments. This group has significant economical, societal and …

Maintaining blood glucose concentration within a relatively narrow range through periods of
fasting or excess nutrient availability is essential to the survival of the organism. This is …

Thyroid disorders and diabetes mellitus often coexist and are closely related. Several
studies have shown a higher prevalence of thyroid disorders in patients with diabetes …

Although it is a widely held thought that direct hormone action on peripheral tissues is
sufficient to mediate the control of nutrient handling, the role of the central nervous system in …

Four grams of glucose circulates in the blood of a person weighing 70 kg. This glucose is
critical for normal function in many cell types. In accordance with the importance of these 4 g …

In the past several years, tremendous progress has been achieved with the discovery and
characterization of vertebrate taste receptors from the T1R and T2R families, which are …