Icariin: A promising natural product in biomedicine and tissue engineering

Z Seyedi, MS Amiri, V Mohammadzadeh… - Journal of Functional …, 2023 - mdpi.com
Among scaffolds used in tissue engineering, natural biomaterials such as plant-based
materials show a crucial role in cellular function due to their biocompatibility and chemical …

AR and PI3K/AKT in prostate cancer: a tale of two interconnected pathways

E Tortorella, S Giantulli, A Sciarra, I Silvestri - International Journal of …, 2023 - mdpi.com
Prostate cancer (PCa) is the most common cancer in men. The androgen receptor (AR) has
a pivotal role in the pathogenesis and progression of PCa. Many therapies targeting AR …

Targeting PI3K/Akt signaling in prostate cancer therapy

M Hashemi, A Taheriazam, P Daneii… - Journal of Cell …, 2023 - Springer
Urological cancers have obtained much attention in recent years due to their mortality and
morbidity. The most common and malignant tumor of urological cancers is prostate cancer …

Addressing the reciprocal crosstalk between the AR and the PI3K/AKT/mTOR signaling pathways for prostate cancer treatment

F Raith, DH O'Donovan, C Lemos, O Politz… - International Journal of …, 2023 - mdpi.com
The reduction in androgen synthesis and the blockade of the androgen receptor (AR)
function by chemical castration and AR signaling inhibitors represent the main treatment …

The extracellular matrix stiffening: a trigger of prostate cancer progression and castration resistance?

C Luthold, T Hallal, DP Labbé, F Bordeleau - Cancers, 2022 - mdpi.com
Simple Summary Prostate cancer is a malignancy that affects a high number of men all over
the world. When indolent, prostate cancer can remain silent for years without needing …

Generating a murine PTEN null cell line to discover the key role of p110β-PAK1 in Castration-Resistant Prostate Cancer invasion

H Wang, Y Zhou, C Chu, J Xiao, S Zheng… - Molecular Cancer …, 2023 - AACR
Although androgen deprivation treatment often effectively decreases prostate cancer,
incurable metastatic castration-resistant prostate cancer (CRPC) eventually occurs. It is …

Important Roles of PI3K/AKT Signaling Pathway and Relevant Inhibitors in Prostate Cancer Progression

R Wang, Z Qu, Y Lv, L Yao, Y Qian, X Zhang… - Cancer …, 2024 - Wiley Online Library
Prostate cancer (PCa) is an extremely common malignant tumor of the male genitourinary
system, originating from the prostate gland epithelium. Male patients are prone to relapse …

Prostate Cancer and PTEN/PI3K/AKT/mTOR Signaling

M Seyed Karimi, F Faghihkhorasani… - … : Molecular Events and …, 2024 - Springer
Despite the generally positive prognosis seen in patients with localized prostate cancer after
surgical intervention and their excellent response to androgen-deprivation treatment, it's …

The amino acid transporter SLC7A5 drives progression of PI3K-mutant intestinal cancer models and enhances response to MAPK-targeted therapy

O Sansom, L Zeiger, C Ford, L Millett, V Meniel… - 2024 - researchsquare.com
Colorectal cancer (CRC) is a complex disease with key oncogenic pathways, including Wnt,
MAPK, and PI3K, co-operating to drive tumour initiation and progression. Loss-of-function …

mTOR Signaling

MS Karimi, F Faghihkhorasani… - … : Molecular Events and … - books.google.com
Despite the generally positive prognosis seen in patients with localized prostate cancer after
surgical intervention and their excellent response to androgen-deprivation treatment, it's …