Stroke is ranked as the second leading cause of death worldwide with an annual mortality
rate of about 5.5 million. Not only does the burden of stroke lie in the high mortality but the …

Omics techniques generate large, multidimensional data that are amenable to analysis by
new informatics approaches alongside conventional statistical methods. Systems theories …

Stroke is a heterogeneous syndrome, and determining risk factors and treatment depends
on the specific pathogenesis of stroke. Risk factors for stroke can be categorized as …

Atherosclerosis is a chronic disease of the arterial wall, and a leading cause of death and
loss of productive life years worldwide. Research into the disease has led to many …

Purpose: Geisinger Health System (GHS) provides an ideal platform for Precision Medicine.
Key elements are the integrated health system, stable patient population, and electronic …

BACKGROUND: A high circulating concentration of interleukin 6 is associated with
increased risk of coronary heart disease. Blockade of the interleukin-6 receptor (IL6R) with a …

Aims: In this article, inflammatory mechanisms that link periodontal diseases to
cardiovascular diseases are reviewed. Methods: This article is a literature review. Results …

Until recently, most envisaged atherosclerosis as a bland arterial collection of cholesterol,
complicated by smooth muscle cell accumulation. According to that concept, endothelial …

Genome-wide association studies have identified 11 common variants convincingly
associated with coronary artery disease (CAD),,,,,,, a modest number considering the …

We conducted a genome-wide association study testing single nucleotide polymorphisms
(SNPs) and copy number variants (CNVs) for association with early-onset myocardial …