Direct substitution of readily available alcohols is recognized as a key research area in
green chemical synthesis. Starting from simple racemic secondary alcohols, the …

The use of 3d metals in de/hydrogenation catalysis has emerged as a competitive field with
respect to “traditional” precious metal catalyzed transformations. The introduction of …

In this review, we summarize the origin and advancements of iridium-catalyzed asymmetric
allylic substitution reactions during the past two decades. Since the first report in 1997, Ir …

In this review, transition metal-catalyzed methodologies and applications that exploit C–C
bond cleavage of vinylcyclopropanes (VCPs) are summarized with a focus on cycloaddition …

The borrowing hydrogen (BH) principle, also called hydrogen auto-transfer, is a powerful
approach which combines transfer hydrogenation (avoiding the direct use of molecular …

Metal-catalyzed reductive coupling has emerged as an alternative to the use of
stoichiometric organometallic reagents in an increasingly diverse range of carbonyl and …

Alkylation reactions represent an important organic transformation to form C–C bonds. In
addition to conventional approaches with alkyl halides or sulfonates as alkylating agents …

In this review, synthetic and mechanistic aspects of key methodologies that exploit C–C
single-bond cleavage of strained ring systems are highlighted. The focus is on transition …

Whereas numerous asymmetric methods for formation of quaternary carbon stereocenters in
cyclic systems have been documented, the construction of acyclic quaternary carbon …

Transition metal-catalyzed substitution of alcohols by N-nucleophiles (or N-alkylation of
amines and related compounds with alcohols) avoids the use of alkylating agents by means …