Viral vectored vaccines: design, development, preventive and therapeutic applications in human diseases
S Wang, B Liang, W Wang, L Li, N Feng… - Signal transduction and …, 2023 - nature.com
Human diseases, particularly infectious diseases and cancers, pose unprecedented
challenges to public health security and the global economy. The development and …
challenges to public health security and the global economy. The development and …
Protection of K18-hACE2 mice and ferrets against SARS-CoV-2 challenge by a single-dose mucosal immunization with a parainfluenza virus 5–based COVID-19 …
D An, K Li, DK Rowe, MCH Diaz, EF Griffin… - Science …, 2021 - science.org
Transmission-blocking vaccines are urgently needed to reduce transmission of SARS-CoV
2, the cause of the COVID-19 pandemic. The upper respiratory tract is an initial site of SARS …
2, the cause of the COVID-19 pandemic. The upper respiratory tract is an initial site of SARS …
Intranasal parainfluenza virus type 5 (PIV5)–vectored RSV vaccine is safe and immunogenic in healthy adults in a phase 1 clinical study
P Spearman, H Jin, K Knopp, P Xiao, MC Gingerich… - Science …, 2023 - science.org
Respiratory syncytial virus (RSV) can lead to serious disease in infants, and no approved
RSV vaccine is available for infants. This first in-human clinical trial evaluated a single dose …
RSV vaccine is available for infants. This first in-human clinical trial evaluated a single dose …
[HTML][HTML] Impact of respiratory syncytial virus infection on host functions: implications for antiviral strategies
MJ Hu, MA Bogoyevitch, DA Jans - Physiological reviews, 2020 - journals.physiology.org
Respiratory syncytial virus (RSV) is one of the leading causes of viral respiratory tract
infection in infants, the elderly, and the immunocompromised worldwide, causing more …
infection in infants, the elderly, and the immunocompromised worldwide, causing more …
Single-dose, intranasal immunization with recombinant parainfluenza virus 5 expressing middle east respiratory syndrome coronavirus (MERS-CoV) spike protein …
K Li, Z Li, C Wohlford-Lenane, DK Meyerholz… - MBio, 2020 - Am Soc Microbiol
Middle East respiratory syndrome coronavirus (MERS-CoV) can cause severe and fatal
acute respiratory disease in humans and remains endemic in the Middle East since first …
acute respiratory disease in humans and remains endemic in the Middle East since first …
CX3CR1 is a receptor for human respiratory syncytial virus in cotton rats
G Green, SM Johnson, H Costello, K Brakel… - Journal of …, 2021 - Am Soc Microbiol
Respiratory syncytial virus (RSV) has been reported to use CX3CR1 in vitro as a receptor on
cultured primary human airway epithelial cultures. To evaluate CX3CR1 as the receptor for …
cultured primary human airway epithelial cultures. To evaluate CX3CR1 as the receptor for …
Recombinant parainfluenza virus 5 expressing clade 2.3. 4.4 b H5 hemagglutinin protein confers broad protection against H5Ny influenza viruses
H Li, H Sun, M Tao, Q Han, H Yu, J Li, X Lu… - Journal of …, 2024 - Am Soc Microbiol
The global circulation of clade 2.3. 4.4 b H5Ny highly pathogenic avian influenza viruses
(HPAIVs) in poultry and wild birds, increasing mammal infections, continues to pose a public …
(HPAIVs) in poultry and wild birds, increasing mammal infections, continues to pose a public …
Structure-based design of glycoprotein subunit vaccines for mumps
Mumps virus (MuV) is a highly contagious paramyxovirus that is endemic in most regions of
the world and continues to cause outbreaks even in highly immunized populations …
the world and continues to cause outbreaks even in highly immunized populations …
A live single-cycle RSV vaccine expressing prefusion F protein
P Lamichhane, ME Schmidt, M Terhüja, SM Varga… - Virology, 2022 - Elsevier
Live-attenuated Respiratory syncytial virus (RSV) vaccines given intranasally have potential
to provide comprehensive protection, including lung-resident immunity. It has however …
to provide comprehensive protection, including lung-resident immunity. It has however …
Parainfluenza virus 5 priming followed by SIV/HIV virus-like-particle boosting induces potent and durable immune responses in nonhuman primates
P Xiao, K Dienger-Stambaugh, X Chen, H Wei… - Frontiers in …, 2021 - frontiersin.org
The search for a preventive vaccine against HIV infection remains an ongoing challenge,
indicating the need for novel approaches. Parainfluenza virus 5 (PIV5) is a paramyxovirus …
indicating the need for novel approaches. Parainfluenza virus 5 (PIV5) is a paramyxovirus …