Over the past decades, the bulk of chemists' interests have been on heterocyclic compounds
and their various derivatives as well as their applications in the pharmaceutical and …

Chagas disease and African sleeping sickness are trypanosomal infections that represent
important public health problems in Latin America and Africa, respectively. The restriction of …

Chagas disease (CD), caused by the intracellular protozoan Trypanosoma cruzi, is a
parasitic illness endemic in Latin America. In the centennial after CD discovery by Carlos …

Nitroimidazoles exhibit high microbicidal activity, but mutagenic, genotoxic and cytotoxic
properties have been attributed to the presence of the nitro group. However, we synthesised …

In this review, we intend to provide a general view of the evolution of experimental studies in
the area of chemotherapy for Chagas disease. We can follow the process of drug …

ABSTRACT From a series of 1, 3, 4-thiadiazole-2-arylhydrazone derivatives of megazol
screened in vitro against Trypanosoma cruzi, eight (S1 to S8) were selected for in vivo …

Megazol is a highly active compound against Trypanosoma cruzi, and has become a core
structure for the design of new trypanocidal agents. Recently, we have identified the new …

Unusual reaction proceeding via the electrophilic activation of nitroalkanes in the presence
of polyphosphoric acid has been discovered. Subsequent nucleophilic attack with …

Herein, we report the design, synthesis and trypanocidal activity of some novel trisubstituted
imidazole derivatives. These heterocyclic derivatives were structurally planned by exploring …

The current treatment of Chagas disease is based on the use of two drugs, nifurtimox (Nfx)
and benznidazole (Bnz), both of which present limited efficacy in the chronic stage of the …