Dual-specificity phosphatases in immunity and infection: an update
R Lang, FAM Raffi - International journal of molecular sciences, 2019 - mdpi.com
Kinase activation and phosphorylation cascades are key to initiate immune cell activation in
response to recognition of antigen and sensing of microbial danger. However, for balanced …
response to recognition of antigen and sensing of microbial danger. However, for balanced …
Regulatory mechanisms and novel therapeutic targeting strategies for protein tyrosine phosphatases
An appropriate level of protein phosphorylation on tyrosine is essential for cells to react to
extracellular stimuli and maintain cellular homeostasis. Faulty operation of signal pathways …
extracellular stimuli and maintain cellular homeostasis. Faulty operation of signal pathways …
Exosomal miR-1246 from glioma patient body fluids drives the differentiation and activation of myeloid-derived suppressor cells
Glioma is a heterogeneous cellular environment in which immune cells play critical roles in
tumor progression. Myeloid-derived suppressor cells (MDSCs) contribute to the formation of …
tumor progression. Myeloid-derived suppressor cells (MDSCs) contribute to the formation of …
Tumor suppressive protein phosphatases in human cancer: Emerging targets for therapeutic intervention and tumor stratification
B Meeusen, V Janssens - The international journal of biochemistry & cell …, 2018 - Elsevier
Aberrant protein phosphorylation is one of the hallmarks of cancer cells, and in many cases
a prerequisite to sustain tumor development and progression. Like protein kinases, protein …
a prerequisite to sustain tumor development and progression. Like protein kinases, protein …
Approaches to study phosphatases
Phosphatases play key roles in normal physiology and diseases. Studying phosphatases
has been both essential and challenging, and the application of conventional genetic and …
has been both essential and challenging, and the application of conventional genetic and …
DUSP8 phosphatase: structure, functions, expression regulation and the role in human diseases
Dual-specificity phosphatases (DUSPs) are a subset of protein tyrosine phosphatases
(PTPs), many of which dephosphorylate the residues of phosphor-serine/threonine and …
(PTPs), many of which dephosphorylate the residues of phosphor-serine/threonine and …
A review of DUSP26: structure, regulation and relevance in human disease
EM Thompson, AW Stoker - International Journal of Molecular Sciences, 2021 - mdpi.com
Dual specificity phosphatases (DUSPs) play a crucial role in the regulation of intracellular
signalling pathways, which in turn influence a broad range of physiological processes …
signalling pathways, which in turn influence a broad range of physiological processes …
Structure–activity relationship of cytotoxic natural products from Indonesian marine sponges
Indonesian marine natural products have been one of the most promising sources in the
race to obtain potential drugs for cancer treatment. One of the primary producers of cytotoxic …
race to obtain potential drugs for cancer treatment. One of the primary producers of cytotoxic …
[HTML][HTML] A versatile flavonoid Quercetin: study of its toxicity and differential gene expression in the liver of mice
Background Flavonoid quercetin is widely found in the plant kingdom. Despite having
beneficial effects, quercetin shows toxic potential and its ambiguous nature justifies further …
beneficial effects, quercetin shows toxic potential and its ambiguous nature justifies further …
The genetic deletion of the Dual Specificity Phosphatase 3 (DUSP3) attenuates kidney damage and inflammation following ischaemia/reperfusion injury in mouse
B Khbouz, P Rowart, L Poma, E Dahlke… - Acta …, 2022 - Wiley Online Library
Abstract Aim Dual Specificity Phosphatase 3 (DUSP3) regulates the innate immune
response, with a putative role in angiogenesis. Modulating inflammation and perfusion …
response, with a putative role in angiogenesis. Modulating inflammation and perfusion …