Are fibrinaloid microclots a cause of autoimmunity in Long Covid and other post-infection diseases?
DB Kell, E Pretorius - Biochemical Journal, 2023 - portlandpress.com
It is now well established that the blood-clotting protein fibrinogen can polymerise into an
anomalous form of fibrin that is amyloid in character; the resultant clots and microclots entrap …
anomalous form of fibrin that is amyloid in character; the resultant clots and microclots entrap …
Aggregation behavior of nanoparticles: Revisiting the phase diagram of colloids
Surface functionalization of metal nanoparticles (NPs), eg, using peptides and proteins, has
recently attracted a considerable attention in the field of design of therapeutics and …
recently attracted a considerable attention in the field of design of therapeutics and …
The ribosome stabilizes partially folded intermediates of a nascent multi-domain protein
Co-translational folding is crucial to ensure the production of biologically active proteins. The
ribosome can alter the folding pathways of nascent polypeptide chains, yet a structural …
ribosome can alter the folding pathways of nascent polypeptide chains, yet a structural …
The Extracts of Polygonum cuspidatum Root and Rhizome Block the Entry of SARS-CoV-2 Wild-Type and Omicron Pseudotyped Viruses via Inhibition of the S …
S Lin, X Wang, RWL Tang, HC Lee, HH Chan… - Molecules, 2022 - mdpi.com
COVID-19, resulting from infection by the SARS-CoV-2 virus, caused a contagious
pandemic. Even with the current vaccines, there is still an urgent need to develop effective …
pandemic. Even with the current vaccines, there is still an urgent need to develop effective …
Innovative non-PrP-targeted drug strategy designed to enhance prion clearance
A Colini Baldeschi, M Zattoni, S Vanni… - Journal of medicinal …, 2022 - ACS Publications
Prion diseases are a group of neurodegenerative disorders characterized by the
accumulation of misfolded prion protein (called PrPSc). Although conversion of the cellular …
accumulation of misfolded prion protein (called PrPSc). Although conversion of the cellular …
Pliability in the m6A-Binding Region Extends Druggability of YTH Domains
G Cazzanelli, A Dalle Vedove, G Spagnolli… - Journal of Chemical …, 2024 - ACS Publications
Epitranscriptomic mRNA modifications affect gene expression, with their altered balance
detected in various cancers. YTHDF proteins contain the YTH reader domain recognizing …
detected in various cancers. YTHDF proteins contain the YTH reader domain recognizing …
Drug design: where we are and future prospects
G Zagotto, M Bortoli - Molecules, 2021 - mdpi.com
Medicinal chemistry is facing new challenges in approaching precision medicine. Several
powerful new tools or improvements of already used tools are now available to medicinal …
powerful new tools or improvements of already used tools are now available to medicinal …
Polygoni multiflori radix extracts inhibit SARS-CoV-2 pseudovirus entry in HEK293T cells and zebrafish larvae
X Wang, S Lin, RWL Tang, HC Lee, HH Chan… - Phytomedicine, 2022 - Elsevier
Background Globally, COVID-19 has caused millions of deaths and led to unprecedented
socioeconomic damage. There is therefore, in addition to vaccination, an urgent need to …
socioeconomic damage. There is therefore, in addition to vaccination, an urgent need to …
Functional, pathogenic, and pharmacological roles of protein folding intermediates
E Biasini, P Faccioli - Proteins: Structure, Function, and …, 2023 - Wiley Online Library
Protein expression and function in eukaryotic cells are tightly harmonized processes
modulated by the combination of different layers of regulation, including transcription …
modulated by the combination of different layers of regulation, including transcription …
The ethanol extract of evodiae fructus and its ingredient, rutaecarpine, inhibit infection of SARS-CoV-2 and Inflammatory Responses
S Lin, X Wang, H Guo, N Dai, RWL Tang… - International Journal of …, 2023 - mdpi.com
COVID-19, derived from SARS-CoV-2, has resulted in millions of deaths and caused
unprecedented socioeconomic damage since its outbreak in 2019. Although the vaccines …
unprecedented socioeconomic damage since its outbreak in 2019. Although the vaccines …