Telomeres are DNA-protein complexes that cap and protect the ends of linear
chromosomes. In almost all species, telomeric DNA has a G/C strand bias, and the short …

Human telomeres are maintained by the shelterin protein complex in which TRF1 and TRF2
bind directly to duplex telomeric DNA. How these proteins find telomeric sequences among …

Previous evidence indicates that telomeres resemble common fragile sites and present a
challenge for DNA replication. The precise impediments to replication fork progression at …

G-quadruplexes (GQs) are non-canonical DNA structures composed of stacks of stabilized G-
tetrads. GQs play an important role in a variety of biological processes and may form at …

Werner syndrome (WS) is a disorder characterized by features of premature aging and
increased cancer that is caused by loss of the RecQ helicase WRN. Telomeres consisting of …

G-quadruplexes and i-motifs are complementary examples of non-canonical nucleic acid
substructure conformations. G-quadruplex thermodynamic stability has been extensively …

Ribosomal RNAs in both prokaryotes and eukaryotes feature numerous repeats of three or
more nucleotides with the same nucleobase (homoiterons). In prokaryotes these repeats are …

During a cell's lifespan, DNA break formation is a common event, associated with many
processes, from replication to apoptosis. Most of DNA breaks are readily repaired, but some …

Human telomeres are composed of GGGTTA repeats and interspersed with variant repeats.
The GGGCTA variant motif was identified in the proximal regions of human telomeres about …

Background: Same-nucleotide repeats (iterons) are strongly expressed in many DNA
regions and RNA classes. These repeats serve importantly in association of polynucleotides …