Cancer is a leading cause of death worldwide. Surgery is the primary treatment approach for
cancer, but the survival rate is very low due to the rapid progression of the disease and …

Radiation is a critical pillar in cancer therapeutics, exerting its anti-tumor DNA-damaging
effects through various direct and indirect mechanisms. Radiation has served as an effective …

Autophagy is a highly conserved metabolic process involved in the degradation of
intracellular components including proteins and organelles. Consequently, it plays a critical …

Autophagy can play a double role in cancerogenesis: it can either inhibit further
development of the disease or protect cells, causing stimulation of tumour growth. This …

Tumor recurrence is a paradoxical function of a machinery, whereby a small proportion of
the cancer cell population enters a resistant, dormant state, persists long-term in this …

Simple Summary Bcl-2/adenovirus E1B 19kDa interacting protein 3 (BNIP3) is a pro-
apoptotic BH3-only protein of the Bcl-2 family. Its function in various biological processes …

Although some clinical studies have reported increased mitochondrial respiration in patients
with fatty liver and early non-alcoholic steatohepatitis (NASH), there is a lack of in vitro …

Background Triple-negative breast cancer (TNBC) represents the most aggressive subtype
of breast cancer and is frequently resistant to therapy, ultimately resulting in treatment …

Purpose Chemotherapy has been used in conjunction with radiation therapy to improve the
treatment outcomes of cancers. Cisplatin (Cis) is a standard treatment that has been used as …

Autophagy is a mechanism involved in many human diseases and in cancers can have a
cytotoxic/cytostatic or protective action, being in the latter case involved in multidrug …