The applications of functional materials-based nano-formulations in the prevention, diagnosis and treatment of chronic inflammation-related diseases
J Wang, R Ni, T Jiang, D Peng, Y Ming… - Frontiers in …, 2023 - frontiersin.org
Chronic inflammation, in general, refers to systemic immune abnormalities most often
caused by the environment or lifestyle, which is the basis for various skin diseases …
caused by the environment or lifestyle, which is the basis for various skin diseases …
The extrafollicular response is sufficient to drive initiation of autoimmunity and early disease hallmarks of lupus
LF Voss, AJ Howarth, TR Wittenborn… - Frontiers in …, 2022 - frontiersin.org
Introduction Many autoimmune diseases are characterized by germinal center (GC)-derived,
affinity-matured, class-switched autoantibodies, and strategies to block GC formation and …
affinity-matured, class-switched autoantibodies, and strategies to block GC formation and …
Amyloid-β aggregates activate peripheral monocytes in mild cognitive impairment
The peripheral immune system is important in neurodegenerative diseases, both in
protecting and inflaming the brain, but the underlying mechanisms remain elusive …
protecting and inflaming the brain, but the underlying mechanisms remain elusive …
DNA corona on nanoparticles leads to an enhanced immunostimulatory effect with implications for autoimmune diseases
F Anees, DA Montoya, DS Pisetsky… - Proceedings of the …, 2024 - National Acad Sciences
Autoimmune and inflammatory diseases are highly complex, limiting treatment and the
development of new therapies. Recent work has shown that cell-free DNA bound to …
development of new therapies. Recent work has shown that cell-free DNA bound to …
Integrating extracellular vesicle and circulating cell‐free DNA analysis using a single plasma aliquot improves the detection of HER2 positivity in breast cancer …
V Mugoni, Y Ciani, O Quaini, S Tomasini… - Journal of …, 2023 - Wiley Online Library
Multi‐analyte liquid biopsies represent an emerging opportunity for non‐invasive cancer
assessment. We developed ONCE (One Aliquot for Circulating Elements), an approach for …
assessment. We developed ONCE (One Aliquot for Circulating Elements), an approach for …
DNA-Binding Proteins and Passenger Proteins in Plasma DNA–Protein Complexes: Imprint of Parental Cells or Key Mediators of Carcinogenesis Processes?
Knowledge of the composition of proteins that interact with plasma DNA will provide a better
understanding of the homeostasis of circulating nucleic acids and the various modes of …
understanding of the homeostasis of circulating nucleic acids and the various modes of …
Design and Self Assembly of Tri-Terpene Peptide Conjugates and Their Interactions with EGFR and EGFR Mutant Receptors: An In Silico and In Vitro Study
MI Rico, BG Goncalves, HL Hunt… - International Journal of …, 2023 - Springer
In this work, we designed new terpenoid-peptide conjugates to target the epidermal growth
factor receptor (EGFR) and its double mutant EGFR T790M/L858R which are implicated in …
factor receptor (EGFR) and its double mutant EGFR T790M/L858R which are implicated in …
[HTML][HTML] Immunoassay for detection of oligomeric proteins
SAN Holme, T Vorup-Jensen, K Juul-Madsen - Journal of Immunological …, 2022 - Elsevier
The mass concentration of specific proteins is often used as a biomarker and play an
important part in diagnostics of inflammatory diseases. Monodisperse proteins are robustly …
important part in diagnostics of inflammatory diseases. Monodisperse proteins are robustly …
Germinal center block exacerbates extrafollicular responses and accelerates autoimmune disease progression in a murine lupus model
LF Voss, AJ Howarth, TR Wittenborn, S Hummelgaard… - bioRxiv, 2022 - biorxiv.org
Systemic lupus erythematosus and numerous other autoimmune diseases are characterized
by affinity-matured, class-switched autoantibodies to nuclear antigens. Such antibodies are …
by affinity-matured, class-switched autoantibodies to nuclear antigens. Such antibodies are …