Protective microglial subset in development, aging, and disease: lessons from transcriptomic studies

A Benmamar-Badel, T Owens… - Frontiers in …, 2020 - frontiersin.org
Microglial heterogeneity has been the topic of much discussion in the scientific community.
Elucidation of their plasticity and adaptability to disease states triggered early efforts to …

Bibliometric review of ATAC-Seq and its application in gene expression

L Luo, M Gribskov, S Wang - Briefings in Bioinformatics, 2022 - academic.oup.com
With recent advances in high-throughput next-generation sequencing, it is possible to
describe the regulation and expression of genes at multiple levels. An assay for transposase …

TREM2 regulates microglial cholesterol metabolism upon chronic phagocytic challenge

AA Nugent, K Lin, B Van Lengerich, S Lianoglou… - Neuron, 2020 - cell.com
Summary Loss-of-function (LOF) variants of TREM2, an immune receptor expressed in
microglia, increase Alzheimer's disease risk. TREM2 senses lipids and mediates myelin …

[HTML][HTML] Dietary suppression of MHC class II expression in intestinal epithelial cells enhances intestinal tumorigenesis

S Beyaz, C Chung, H Mou, KE Bauer-Rowe… - Cell Stem Cell, 2021 - cell.com
Little is known about how interactions of diet, intestinal stem cells (ISCs), and immune cells
affect early-stage intestinal tumorigenesis. We show that a high-fat diet (HFD) reduces the …

Alzheimer's-associated PLCγ2 is a signaling node required for both TREM2 function and the inflammatory response in human microglia

BJ Andreone, L Przybyla, C Llapashtica, A Rana… - Nature …, 2020 - nature.com
Human genetic data indicate that microglial dysfunction contributes to the pathology of
Alzheimer's disease (AD), exemplified by the identification of coding variants in triggering …

Optical pooled screens in human cells

D Feldman, A Singh, JL Schmid-Burgk, RJ Carlson… - Cell, 2019 - cell.com
Genetic screens are critical for the systematic identification of genes underlying cellular
phenotypes. Pooling gene perturbations greatly improves scalability but is not compatible …

Mechanisms of readthrough mitigation reveal principles of GCN1-mediated translational quality control

MBD Müller, P Kasturi, GG Jayaraj, FU Hartl - Cell, 2023 - cell.com
Readthrough into the 3′ untranslated region (3′ UTR) of the mRNA results in the
production of aberrant proteins. Metazoans efficiently clear readthrough proteins, but the …

[HTML][HTML] A modular master regulator landscape controls cancer transcriptional identity

EO Paull, A Aytes, SJ Jones, PS Subramaniam… - Cell, 2021 - cell.com
Despite considerable efforts, the mechanisms linking genomic alterations to the
transcriptional identity of cancer cells remain elusive. Integrative genomic analysis, using a …

[HTML][HTML] Integrative functional genomic analyses identify genetic variants influencing skin pigmentation in Africans

Y Feng, N Xie, F Inoue, S Fan, J Saskin, C Zhang… - Nature Genetics, 2024 - nature.com
Skin color is highly variable in Africans, yet little is known about the underlying molecular
mechanism. Here we applied massively parallel reporter assays to screen 1,157 candidate …

Systematic mapping of nuclear domain-associated transcripts reveals speckles and lamina as hubs of functionally distinct retained introns

AR Barutcu, M Wu, U Braunschweig, BJA Dyakov… - Molecular cell, 2022 - cell.com
The nucleus is highly compartmentalized through the formation of distinct classes of
membraneless domains. However, the composition and function of many of these structures …