Protective microglial subset in development, aging, and disease: lessons from transcriptomic studies
A Benmamar-Badel, T Owens… - Frontiers in …, 2020 - frontiersin.org
Microglial heterogeneity has been the topic of much discussion in the scientific community.
Elucidation of their plasticity and adaptability to disease states triggered early efforts to …
Elucidation of their plasticity and adaptability to disease states triggered early efforts to …
Bibliometric review of ATAC-Seq and its application in gene expression
L Luo, M Gribskov, S Wang - Briefings in Bioinformatics, 2022 - academic.oup.com
With recent advances in high-throughput next-generation sequencing, it is possible to
describe the regulation and expression of genes at multiple levels. An assay for transposase …
describe the regulation and expression of genes at multiple levels. An assay for transposase …
TREM2 regulates microglial cholesterol metabolism upon chronic phagocytic challenge
Summary Loss-of-function (LOF) variants of TREM2, an immune receptor expressed in
microglia, increase Alzheimer's disease risk. TREM2 senses lipids and mediates myelin …
microglia, increase Alzheimer's disease risk. TREM2 senses lipids and mediates myelin …
[HTML][HTML] Dietary suppression of MHC class II expression in intestinal epithelial cells enhances intestinal tumorigenesis
Little is known about how interactions of diet, intestinal stem cells (ISCs), and immune cells
affect early-stage intestinal tumorigenesis. We show that a high-fat diet (HFD) reduces the …
affect early-stage intestinal tumorigenesis. We show that a high-fat diet (HFD) reduces the …
Alzheimer's-associated PLCγ2 is a signaling node required for both TREM2 function and the inflammatory response in human microglia
BJ Andreone, L Przybyla, C Llapashtica, A Rana… - Nature …, 2020 - nature.com
Human genetic data indicate that microglial dysfunction contributes to the pathology of
Alzheimer's disease (AD), exemplified by the identification of coding variants in triggering …
Alzheimer's disease (AD), exemplified by the identification of coding variants in triggering …
Optical pooled screens in human cells
Genetic screens are critical for the systematic identification of genes underlying cellular
phenotypes. Pooling gene perturbations greatly improves scalability but is not compatible …
phenotypes. Pooling gene perturbations greatly improves scalability but is not compatible …
Mechanisms of readthrough mitigation reveal principles of GCN1-mediated translational quality control
Readthrough into the 3′ untranslated region (3′ UTR) of the mRNA results in the
production of aberrant proteins. Metazoans efficiently clear readthrough proteins, but the …
production of aberrant proteins. Metazoans efficiently clear readthrough proteins, but the …
[HTML][HTML] A modular master regulator landscape controls cancer transcriptional identity
Despite considerable efforts, the mechanisms linking genomic alterations to the
transcriptional identity of cancer cells remain elusive. Integrative genomic analysis, using a …
transcriptional identity of cancer cells remain elusive. Integrative genomic analysis, using a …
[HTML][HTML] Integrative functional genomic analyses identify genetic variants influencing skin pigmentation in Africans
Skin color is highly variable in Africans, yet little is known about the underlying molecular
mechanism. Here we applied massively parallel reporter assays to screen 1,157 candidate …
mechanism. Here we applied massively parallel reporter assays to screen 1,157 candidate …
Systematic mapping of nuclear domain-associated transcripts reveals speckles and lamina as hubs of functionally distinct retained introns
The nucleus is highly compartmentalized through the formation of distinct classes of
membraneless domains. However, the composition and function of many of these structures …
membraneless domains. However, the composition and function of many of these structures …