Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited
cause of kidney failure, accounting for 5%-10% of cases. Predicting which patients with …

A lesser known but crucially important downstream effect of Rho family GTPases is the
regulation of gene expression. This major role is mediated via the cytoskeleton, the …

Autosomal dominant polycystic kidney disease (ADPKD), characterized by progressive cyst
formation/expansion, results in enlarged kidneys and often end stage kidney disease …

BACKGROUND A treatment option for autosomal dominant polycystic kidney disease
(ADPKD) has highlighted the need to identify rapidly progressive patients. Kidney size/age …

Rationale & Objective Autosomal dominant polycystic kidney disease (ADPKD) is a common
inherited disorder that leads to kidney failure and has few treatment options. Metformin is …

Using age-and height-adjusted total kidney volume, the Mayo Clinic Imaging Classification
provides a validated approach to assess the risk of chronic kidney disease (CKD) …

Autosomal dominant polycystic kidney disease (ADPKD), primarily due to PKD1 or PKD2
mutations, causes progressive kidney cyst development and kidney failure. There is …

Methods We conducted a cross-sectional analysis among members of the Kaiser
Permanente Southern California (KPSC) health system between January 1, 2002 and …

Autosomal dominant polycystic kidney disease constitutes the most prevalent hereditary
kidney disease, associated with high rates of morbidity leading eventually to end-stage renal …

Background Autosomal dominant polycystic kidney disease (ADPKD) is the most common
renal monogenic disease, characterized by bilateral accumulation of renal fluid-filled cysts …