Immune regulatory function of B cells
C Mauri, A Bosma - Annual review of immunology, 2012 - annualreviews.org
B cells are regarded for their capacity to produce antibody. However, recent advances in B
cell biology have capitalized on old findings and demonstrated that B cells also release a …
cell biology have capitalized on old findings and demonstrated that B cells also release a …
The 'short'history of regulatory B cells
C Mauri, MR Ehrenstein - Trends in immunology, 2008 - cell.com
The maintenance of tolerance is the sine qua non of a sophisticated regulatory apparatus to
prevent or dampen overzealous immune responses. In addition to the ability of B cells to …
prevent or dampen overzealous immune responses. In addition to the ability of B cells to …
CD19+ CD24hiCD38hi B cells exhibit regulatory capacity in healthy individuals but are functionally impaired in systemic lupus erythematosus patients
PA Blair, LY Noreña, F Flores-Borja, DJ Rawlings… - immunity, 2010 - cell.com
The immunosuppressive function of regulatory B cells has been shown in several murine
models of chronic inflammation, including collagen-induced arthritis, inflammatory bowel …
models of chronic inflammation, including collagen-induced arthritis, inflammatory bowel …
IL-21 induces differentiation of human naive and memory B cells into antibody-secreting plasma cells
R Ettinger, GP Sims, AM Fairhurst… - The Journal of …, 2005 - journals.aai.org
IL-21 is a type I cytokine that influences the function of T cells, NK cells, and B cells. In this
study, we report that IL-21 plays a major role in stimulating the differentiation of human B …
study, we report that IL-21 plays a major role in stimulating the differentiation of human B …
Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases
YR Li, J Li, SD Zhao, JP Bradfield, FD Mentch… - Nature medicine, 2015 - nature.com
Genome-wide association studies (GWASs) have identified hundreds of susceptibility
genes, including shared associations across clinically distinct autoimmune diseases. We …
genes, including shared associations across clinically distinct autoimmune diseases. We …
Essential role of IL-21 in B cell activation, expansion, and plasma cell generation during CD4+ T cell-B cell collaboration
During T cell-B cell collaboration, plasma cell (PC) differentiation and Ig production are
known to require T cell-derived soluble factors. However, the exact nature of the cytokines …
known to require T cell-derived soluble factors. However, the exact nature of the cytokines …
Selective targeting of B cells with agonistic anti-CD40 is an efficacious strategy for the generation of induced regulatory T2-like B cells and for the suppression of lupus …
PA Blair, KA Chavez-Rueda, JG Evans… - The Journal of …, 2009 - journals.aai.org
We have previously reported that IL-10+ regulatory B cells, known to play an important role
in controlling autoimmunity and inflammatory disorders, are contained within the transitional …
in controlling autoimmunity and inflammatory disorders, are contained within the transitional …
Abnormal germinal center reactions in systemic lupus erythematosus demonstrated by blockade of CD154-CD40 interactions
AC Grammer, R Slota, R Fischer, H Gur… - The Journal of …, 2003 - Am Soc Clin Investig
To determine the role of CD154-CD40 interactions in the B cell overactivity exhibited by
patients with active systemic lupus erythematosus (SLE), CD19+ peripheral B cells were …
patients with active systemic lupus erythematosus (SLE), CD19+ peripheral B cells were …
Prospects for CD40-directed experimental therapy of human cancer
AW Tong, MJ Stone - Cancer gene therapy, 2003 - nature.com
CD40, a member of the tumor necrosis factor receptor (TNF-R) family, is a surface receptor
best known for its capacity to initiate multifaceted activation signals in normal B cells and …
best known for its capacity to initiate multifaceted activation signals in normal B cells and …
Toll-like receptor signaling and immune regulatory lymphocytes in periodontal disease
Y Gu, X Han - International journal of molecular sciences, 2020 - mdpi.com
Periodontitis is known to be initiated by periodontal microbiota derived from biofilm
formation. The microbial dysbiotic changes in the biofilm trigger the host immune and …
formation. The microbial dysbiotic changes in the biofilm trigger the host immune and …