B cells are regarded for their capacity to produce antibody. However, recent advances in B
cell biology have capitalized on old findings and demonstrated that B cells also release a …

The maintenance of tolerance is the sine qua non of a sophisticated regulatory apparatus to
prevent or dampen overzealous immune responses. In addition to the ability of B cells to …

The immunosuppressive function of regulatory B cells has been shown in several murine
models of chronic inflammation, including collagen-induced arthritis, inflammatory bowel …

IL-21 is a type I cytokine that influences the function of T cells, NK cells, and B cells. In this
study, we report that IL-21 plays a major role in stimulating the differentiation of human B …

Genome-wide association studies (GWASs) have identified hundreds of susceptibility
genes, including shared associations across clinically distinct autoimmune diseases. We …

During T cell-B cell collaboration, plasma cell (PC) differentiation and Ig production are
known to require T cell-derived soluble factors. However, the exact nature of the cytokines …

We have previously reported that IL-10+ regulatory B cells, known to play an important role
in controlling autoimmunity and inflammatory disorders, are contained within the transitional …

To determine the role of CD154-CD40 interactions in the B cell overactivity exhibited by
patients with active systemic lupus erythematosus (SLE), CD19+ peripheral B cells were …

CD40, a member of the tumor necrosis factor receptor (TNF-R) family, is a surface receptor
best known for its capacity to initiate multifaceted activation signals in normal B cells and …

Periodontitis is known to be initiated by periodontal microbiota derived from biofilm
formation. The microbial dysbiotic changes in the biofilm trigger the host immune and …