Ecology and evolution of Mycobacterium tuberculosis

S Gagneux - Nature Reviews Microbiology, 2018 - nature.com
Tuberculosis (TB) is the number one cause of human death due to an infectious disease.
The causative agents of TB are a group of closely related bacteria known as the …

The epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant, extensively drug-resistant, and incurable tuberculosis

K Dheda, T Gumbo, G Maartens, KE Dooley… - The lancet Respiratory …, 2017 - thelancet.com
Global tuberculosis incidence has declined marginally over the past decade, and
tuberculosis remains out of control in several parts of the world including Africa and Asia …

Evolution of Drug-Resistant Mycobacterium tuberculosis Strains and Their Adaptation to the Human Lung Environment

A Allué-Guardia, JI García, JB Torrelles - Frontiers in Microbiology, 2021 - frontiersin.org
In the last two decades, multi (MDR), extensively (XDR), extremely (XXDR) and total (TDR)
drug-resistant Mycobacterium tuberculosis (M. tb) strains have emerged as a threat to public …

Antimicrobial resistance in Mycobacterium tuberculosis: mechanistic and evolutionary perspectives

SM Gygli, S Borrell, A Trauner… - FEMS microbiology …, 2017 - academic.oup.com
Antibiotic-resistant Mycobacterium tuberculosis strains are threatening progress in
containing the global tuberculosis epidemic. Mycobacterium tuberculosis is intrinsically …

Evolution of drug resistance in Mycobacterium tuberculosis: a review on the molecular determinants of resistance and implications for personalized care

N Dookie, S Rambaran, N Padayatchi… - Journal of …, 2018 - academic.oup.com
Abstract Drug-resistant TB (DR-TB) remains a significant challenge in TB treatment and
control programmes worldwide. Advances in sequencing technology have significantly …

Drug resistant tuberculosis: Implications for transmission, diagnosis, and disease management

D Liebenberg, BG Gordhan, BD Kana - Frontiers in cellular and …, 2022 - frontiersin.org
Drug resistant tuberculosis contributes significantly to the global burden of antimicrobial
resistance, often consuming a large proportion of the healthcare budget and associated …

Within-host evolution of bacterial pathogens

X Didelot, AS Walker, TE Peto, DW Crook… - Nature Reviews …, 2016 - nature.com
Whole-genome sequencing has opened the way for investigating the dynamics and
genomic evolution of bacterial pathogens during the colonization and infection of humans …

Evolutionary history and global spread of the Mycobacterium tuberculosis Beijing lineage

M Merker, C Blin, S Mona, N Duforet-Frebourg… - Nature …, 2015 - nature.com
Mycobacterium tuberculosis strains of the Beijing lineage are globally distributed and are
associated with the massive spread of multidrug-resistant (MDR) tuberculosis in Eurasia …

A robust SNP barcode for typing Mycobacterium tuberculosis complex strains

F Coll, R McNerney, JA Guerra-Assunção… - Nature …, 2014 - nature.com
Strain-specific genomic diversity in the Mycobacterium tuberculosis complex (MTBC) is an
important factor in pathogenesis that may affect virulence, transmissibility, host response …

Robust barcoding and identification of Mycobacterium tuberculosis lineages for epidemiological and clinical studies

G Napier, S Campino, Y Merid, M Abebe… - Genome medicine, 2020 - Springer
Background Tuberculosis, caused by bacteria in the Mycobacterium tuberculosis complex
(MTBC), is a major global public health burden. Strain-specific genomic diversity in the …