Recent advancement in chitosan-based nanoparticles for improved oral bioavailability and bioactivity of phytochemicals: Challenges and perspectives

SS Imam, S Alshehri, MM Ghoneim, A Zafar… - Polymers, 2021 - mdpi.com
The excellent therapeutic potential of a variety of phytochemicals in different diseases has
been proven by extensive studies throughout history. However, most phytochemicals are …

[HTML][HTML] Cod liver oil nano-structured lipid carriers (Cod-NLCs) as a promising platform for nose to brain delivery: Preparation, in vitro optimization, ex vivo cytotoxicity …

E Taha, SA Nour, W Mamdouh, AA Selim… - International Journal of …, 2023 - Elsevier
Nano-structured lipid carriers containing zopiclone were prepared as a targeted drug
delivery system to convey zopiclone directly to brain via nasal route. Nano-structured lipid …

Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) for the delivery of bioactives sourced from plants: part II–applications and preclinical …

F Fathi, TOX Machado, H de AC Kodel… - Expert Opinion on …, 2024 - Taylor & Francis
Introduction Numerous purified bioactive compounds, crude extracts, and essential oils have
demonstrated potent antioxidant, antimicrobial, anti-inflammatory, and antiviral properties …

Augmented efficiency of azithromycin for MRSA ocular infections management: Limonene-based nanostructured lipid carriers in-situ approach

KK Abla, SM Hijazi, MM Mehanna - Journal of Drug Delivery Science and …, 2023 - Elsevier
Staphylococcus aureus (S. aureus) is the main pathogen that leads to serious ocular
infectious disorders such as endophthalmitis and keratitis. A major obstacle in managing …

Chitosan modified 5-fluorouracil nanostructured lipid carriers for treatment of diabetic retinopathy in rats: A new dimension to an anticancer drug

DS Sharma, S Wadhwa, M Gulati, B Kumar… - International journal of …, 2023 - Elsevier
Diabetic retinopathy (DR) is one of the chronic complications of diabetes. It includes retinal
blood vessels' damage. If untreated, it leads to loss of vision. The existing treatment …

A nanoemulsion based transdermal delivery of insulin: Formulation development, optimization, in-vitro permeation across Strat-M® membrane and its …

FR Ali, MH Shoaib, SA Ali, RI Yousuf, F Siddiqui… - Journal of Drug Delivery …, 2022 - Elsevier
Peptides and proteins are mainly delivered through the parenteral route which is painful and
reduces patient compliance. The aim was to explore the feasibility of using nanoemulsion as …

Formulation of piperine nanoparticles: In vitro breast cancer cell line and in vivo evaluation

I Kazmi, FA Al-Abbasi, SS Imam, M Afzal, MS Nadeem… - Polymers, 2022 - mdpi.com
Piperine (PPN), one of the most investigated phytochemicals, is known to have excellent
therapeutic efficacy against a variety of ailments including breast cancer. However, its …

An update on nanoparticle formulation design of piperine to improve its oral bioavailability: a review

AK Nugroho, N Kusumorini… - Iraqi Journal of …, 2023 - bijps.uobaghdad.edu.iq
Piperine, a crystalline alkaloid compound isolated from Piper nigrum, piper longum, and
other types of piper, has had many fabulous pharmacological advantages for preventing and …

Antiproliferative activity of syringic acid-loaded nanostructured lipid carriers against MCF-7 human breast carcinoma cells.

S Jha, A Prabakaran, RK Sahoo, S Batheja… - Journal of Drug Delivery …, 2024 - Elsevier
Syringic acid (SA) is a phenolic herbal compound known to exert antiproliferative properties.
However, its poor aqueous solubility and low bioavailability lead to limited therapeutic …

A Dual Therapy of Nanostructured Lipid Carrier Loaded with Teriflunomide—A Dihydro-Orotate Dehydrogenase Inhibitor and an miR-155-Antagomir in Cuprizone …

TS Koduru, VN Gupta, B Veeranna, S Seetharaman - Pharmaceutics, 2023 - mdpi.com
The effective treatment of central nervous system (CNS) disorders such as multiple sclerosis
(MS) has been challenging due to the limited ability of therapeutic agents to cross the blood …